Results 111 to 120 of about 585,431 (288)

In Situ Lipoprotein‐seeking Dye for in Vivo Real‐Time Imaging of Lipid Dysregulation Diseases

Advanced Science, EarlyView.
This study develops lipoprotein‐seeking NIR‐II dyes that specifically bind circulating lipoproteins. These dyes form ultra‐stable complexes with endogenous lipoprotein, enabling real‐time, high‐contrast imaging of fatty liver and atherosclerotic plaques. Tunable binding kinetics allow customized imaging windows.
Yijing Du, Zetao Dang, Baofeng Xu, Jiajun Xu, Dan Wang, Yuewei Zhang, Shoujun Zhu   +6 more
wiley   +1 more source

P1504Discordant low-density lipoprotein particle number versus low-density lipoprotein cholesterol is associated with increased C-reactive protein and poorer outcomes [PDF]

, 2017
Jeffrey W. Meeusen, Leslie J. Donato, Linnea M. Baudhuin, Allan S. Jaffe   +3 more
openalex   +1 more source

Parallel Genome‐Wide CRISPR Screens Reveal SORL1 and ZFYVE19 as Sequential Host Determinants of Salmonella Infection

Advanced Science, EarlyView.
To distinguish how Salmonella invades cells vs how it survives long‐term, a parallel CRISPR screening platform is developed. This approach reveals the host proteins that the bacterium exploits at different stages of infection. The study identifies SORL1 as a novel host factor for invasion and demonstrates that blocking it with an antibody effectively ...
Sehee Yun, Seoyeon Kim, Seonggyu Kim, Minsoo Noh, Dae‐Kyum Kim, Eun‐Jin Lee, Hunsang Lee   +6 more
wiley   +1 more source

Classification and Prediction of Low-Density Lipoprotein Cholesterol LDL-C in The Palestinian Patients Using Machine Learning Techniques

, 2021
Sanad Malaysha, Mohammed Awad, Rami Hadrob, B Ference, H Ginsberg, I Graham, K Ray, C Packard, E Bruckert, A Catapano, M Vrbaki, R Doroslovaki, A Kupusinac, E Stoki, D Iveti, V Carey, L Bishop, N Laranjo, B Harshfield, C Kwiat, F Sacks, P Thaisiam, J Sothornwit, S Charoensri, S Pattanapairoj, P Kotruchin, C Pongchaiyakul, T Lee, J Kim, Y Uh, H Lee, J Wiens, E Shenoy, J Ma, J Yu, G Hao, D Wang, Y Sun, J Lu, F Lin, S Mohan, C Thirumalai, G Srivastava, T Lee, J Kim, Y Uh, H Lee, R Wadhera, D Steen, I Khan, R Giugliano, J Foody, T Bathen, J Krane, T Engan, K Bjerve, D Axelson, J Liu, Y Chen, L Lan, B Lin, W Chen, M Wang, Y Duan, I Hamdan, M Awad, W Sabbah, H Qteat, M Awad, A Schein, L Ungar, A Alabdallah, M Awad, S Suthaharan, Y Song, L Ying, H Sak, A Senior, F Beaufays, S Li, W Li, C Cook, C Zhu, Y Gao, M Awad, A Abuhasan, M Awad, I Qasrawi, M Awad, J Jang   +89 more
openalex   +1 more source

A Novel CYP2E1 Inhibitor, 4‐Methyl‐5‐Acetylthiazole (Q11), Alleviates Obesity Via Modulating Adipose Inflammation and Mitochondrial Dysfunction

Advanced Science, EarlyView.
Obesity involves chronic inflammation and mitochondrial dysfunction. This study identifies cytochrome P450 2E1 (CYP2E1) as a novel inflammatory target in adipose tissue. Its activity increases in obese mice and correlates with inflammation and mitochondrial impairment.
Jinhuan Qiu, Liyuan Gao, Liyang Wang, Xueke Wang, Lin Jia, Mengyan Deng, Liming Tang, Qiang Wen, Na Gao, Haiwei Xu, Hailing Qiao   +10 more
wiley   +1 more source

Association of low-density lipoprotein cholesterol within the normal range and NAFLD in the non-obese Chinese population: a cross-sectional and longitudinal study [PDF]

, 2016
Dan‐Qin Sun, Shengjie Wu, Wen‐Yue Liu, Liren Wang, Yi‐Ran Chen, Dong-Chu Zhang, Martin Braddock, Keqing Shi, Dan Song, Ming‐Hua Zheng   +9 more
openalex   +1 more source

[Low density lipoprotein apheresis].

Medicina (Kaunas, Lithuania), 2004
Increased blood cholesterol concentration is one of the main factors in ischemic heart disease, development of which is determined by atherosclerotic changes in coronary vessels. Diet and treatment with 3-hydroxi-3-metilglutaril coenzyme A (HMG-CoA) reductase inhibitors helps to reduce low density lipoprotein cholesterol (LDL-Ch) blood concentration up
Remigijus, Zaliūnas, Rimvydas, Slapikas, Olivija, Gustiene, Jonas, Siurkus, Eduardas, Vaitkus   +4 more
openaire   +1 more source

A Novel 10‐Protein Score for Liver Fat Content Predicts Cardiovascular‐Kidney‐Metabolic Disease Risk

Advanced Science, EarlyView.
A novel 10‐protein plasma score precisely quantifies liver fat, outperforming the fatty liver index. It robustly predicts the risk of numerous cardiovascular‐kidney‐metabolic diseases and integrates with genetic data for precision prevention, offering a practical alternative to magnetic resonance imaging (MRI). Abstract Liver fat content (LFC) is a key
Xiaoqin Gan, Yuanxiu Wei, Yiting Wu, Xinyue Su, Gangling Wang, Sisi Yang, Ziliang Ye, Yanjun Zhang, Hao Xiang, Yu Huang, Yiwei Zhang, Yuanyuan Zhang, Xianhui Qin   +12 more
wiley   +1 more source

Demonstration of an abnormality of C apoprotein of very low density lipoprotein in patients with gout. [PDF]

, 1985
David G. Macfarlane, C. A. Midwinter, Paul Dieppe, C. Bolton, M Hartog   +4 more
openalex   +1 more source

Label‐Free Leukocyte Biophysical Profiling Using Impedance‐Deformability Cytometry for Rapid Cardiovascular Risk Stratification

Advanced Science, EarlyView.
This study presents an impedance‐based single‐cell profiling platform that quantifies the electrical and mechanical properties of neutrophils across in vitro, in vivo, and clinical samples. The approach reveals distinct biophysical alterations associated with type 2 diabetes (T2DM) and cardiovascular complications, suggesting its potential utility for ...
Linwei He, Hui Min Tay, Feng Chen, Hong Sheng Cheng, Liang De Wang, Qiqi Nam, Arunachalam Thannirmalai, Lingyan Gong, Aram J. Chung, Nguan Soon Tan, King Ho Holden Li, Rinkoo Dalan, Siu Ling Wong, Han Wei Hou   +13 more
wiley   +1 more source