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Low Density Lipoproteins and Hypercholesterolemia
1989Coronary and vascular disease of atherosclerotic origin are the main causes of death and at the same time the most frequent reasons for early invalidity in the Federal Republic of Germany and other industrialized nations. In particular, coronary heart disease (CHD) is the major cause of death in middle-aged men.
G, Assmann, H, Funke, G, Schmitz
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The low density lipoprotein receptor
Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1989The study of familial hypercholesterolemia at the molecular level has led to its advancement from a clinical syndrome to a fascinating experimental system. FH was first described 50 years ago by Carl Müller who concluded that the disease produces high plasma cholesterol levels and myocardial infarctions in young people, and is transmitted as an ...
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Low-density Lipoproteins in Atherogenesis
2000It is well established that high levels of plasma cholesterol, particularly those associated with low-density lipoprotein (LDL), increase the risk of developing atherosclerosis. It is also clear that lowering plasma cholesterol levels can arrest or even reverse the progression of the disease [1,2].
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Low Density Lipoprotein Apheresis
2013Therapeutic plasma exchange volume is usually 3–5 L/session. Removal of positively charged particles as well as low density lipoprotein cholesterol improves focal segmental glomerulosclerosis and peripheral arterial disease. Angiotensin converting enzyme (ACE) inhibitors should be discontinued at least 2–3 days prior to low density ...
Kenjiro Honda, Kent Doi
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[Modified low-density lipoprotein].
Nihon rinsho. Japanese journal of clinical medicine, 1995Oxidative modification of low-density lipoprotein (LDL) has been implicated in the pathogenesis of coronary artery disease (CAD). Macrophages take up oxidized LDL via scavenger receptors, which is not regulated by cellular cholesterol contents, and oxidized LDL stimulates cholesterol esterification and this results in cellular cholesterol accumulation ...
H, Yoshida, H, Nakamura
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Mammalian Low Density Lipoproteins
1976During the past few years considerable advances have been made in the study of mammalian plasma low density lipoproteins. Although human LDL is of prime interest, mainly because of its association with atherosclerosis, many studies can most satisfactorily be carried out on animals, including work on the mechanisms of LDL production and metabolism, the ...
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Oxidised Low Density Lipoproteins
1993The evidence for the oxidative modification of low density lipoprotein (LDL) and its subsequent recognition by the scavenger receptors on macrophages in vitro is clear. The presence of oxidatively modified LDL in atherosclerotic lesions is well-recognised. However, the mechanism whereby LDL becomes oxidised in vivo is yet to be clarified.
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Lipoprotein Metabolism: Chylomicrons, Very-Low-Density Lipoproteins and Low-Density Lipoproteins
2015Verne Schumaker, Audra Lembertas
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