Results 321 to 330 of about 1,184,339 (384)

The low-density lipoprotein pathway and its relation to atherosclerosis.

Annual Review of Biochemistry, 1977
PERSPECTIVES AND SUMMARY 898 LDL, THE MAJOR CHOLESTEROL-CARRYING LIPOPROTEIN OF HUMAN PLASMA . 901 Structure of Plasma LDL .. ... .... 901 Origin of Plasma LDL 902 Catabolism of Plasma LDL 902 THE LDL PATHWAY IN HUMAN FIBROBLASTS ..... ...... 903 The LDL
J. Goldstein, M. Brown
semanticscholar   +1 more source

Low-density lipoprotein subclass patterns and risk of myocardial infarction.

Journal of the American Medical Association (JAMA), 1988
The association of low-density lipoprotein (LDL) subclass patterns with coronary heart disease was investigated in a case-control study of nonfatal myocardial infarction.
M. Austin, J. Breslow, C. Hennekens, Julie E. Buring, W. Willett, R. Krauss   +5 more
semanticscholar   +1 more source

Low-density lipoprotein heterogeneity

Baillière's Clinical Endocrinology and Metabolism, 1995
As a key feature of the ALP, a raised level of small, dense LDL forms part of what is potentially the most common collection of lipoprotein abnormalities to influence the risk of CHD in the general population. The consistency of the association between a prevalence of small, dense LDL and increased risk of CHD is impressive, though the practical ...
openaire   +3 more sources

Low Density Lipoproteins and Hypercholesterolemia

1989
Coronary and vascular disease of atherosclerotic origin are the main causes of death and at the same time the most frequent reasons for early invalidity in the Federal Republic of Germany and other industrialized nations. In particular, coronary heart disease (CHD) is the major cause of death in middle-aged men.
H. Funke, G. Assmann, G. Schmitz
openaire   +3 more sources

Oxidized low-density lipoprotein as a biomarker of cardiovascular diseases

Critical reviews in clinical laboratory sciences, 2015
Atherosclerosis is a life-long illness that begins with risk factors, which in turn contribute to the development of subclinical disease, followed by the establishment of overt cardiovascular disease (CVD).
A. Trpković, I. Resanović, J. Stanimirovic, D. Radak, S. Mousa, D. Cenić-Milosević, D. Jevremović, E. Isenovic   +7 more
semanticscholar   +1 more source

The low density lipoprotein receptor

Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1989
The study of familial hypercholesterolemia at the molecular level has led to its advancement from a clinical syndrome to a fascinating experimental system. FH was first described 50 years ago by Carl Müller who concluded that the disease produces high plasma cholesterol levels and myocardial infarctions in young people, and is transmitted as an ...
openaire   +3 more sources

On the metabolic conversion of human plasma very low density lipoprotein to low density lipoprotein

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1973
Abstract The relationship of 125I-labelled apoproteins of very low density lipoprotein to that of other lipoproteins was studied in humans during steady-state conditions and following heparin injection. Heterogeneous metabolism of very low density lipo-protein apoproteins in normal individuals was apparent during steady-state conditions ...
Robert I. Levy, Frank T. Lindgren, Shlomo Eisenberg, David W. Bilheimer   +3 more
openaire   +3 more sources

Mild autoxidation of low density lipoproteins

Pharmaceutica Acta Helvetiae, 1996
The autoxidation of low density lipoproteins was investigated in a closed system, with limited amount of oxygen. The concentrations of several components were monitored: oxygen, aldehydic oxidation products and alpha-tocopherol. The concentration of lipid radicals generated in the processes of lipid peroxidation was monitored by the EPR spin trapping ...
Tatjana Ukrainczyk, Dubravka Krilov, Janko N. Herak   +2 more
openaire   +4 more sources

The affinity of low-density lipoproteins and of very-low-density lipoprotein remnants for the low-density lipoprotein receptor in homozygous familial defective apolipoprotein B-100

Atherosclerosis, 1995
We have identified two familial defective apo B-100 (FDB) homozygotes by DNA sequencing and have measured affinity of low-density lipoproteins (LDL) and very-low-density lipoprotein (VLDL) remnants for the LDL receptor in vitro. The patients were a 66-year-old man with coronary heart disease (plasma cholesterol level, 9.5 mmol/l before treatment) and ...
John J. Gallagher, Nicolas B. Myant
openaire   +2 more sources

Receptors for modified low-density lipoproteins on human endothelial cells: different recognition for acetylated low-density lipoprotein and oxidized low-density lipoprotein

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1991
We examined the uptake pathway of acetylated low-density lipoprotein and oxidatively modified LDL (oxidized LDL) in human umbilical vein endothelial cells in culture. Proteolytic degradation of 125I-labeled Ac-LDL or Ox-LDL in the confluent monolayer of human endothelial cells was time-dependent and showed saturation kinetics in the dose-response ...
Hidenori Arai, Noriaki Kume, Chuichi Kawai, Toru Kita   +3 more
openaire   +3 more sources