Results 321 to 330 of about 1,439,975 (404)

Simvastatin overcomes the pPCK1‐pLDHA‐SPRINGlac axis‐mediated ferroptosis and chemo‐immunotherapy resistance in AKT‐hyperactivated intrahepatic cholangiocarcinoma

Cancer Communications, EarlyView.
Abstract Background Intrahepatic cholangiocarcinoma (ICC) is a challenging cancer with an increasing incidence. The Phase III TOPAZ‐1/KEYNOTE‐966 study demonstrated chemo‐immunotherapy (CIT) as a significant advancement, potentially replacing traditional chemotherapy for advanced biliary tract cancer.
Jinghan Zhu, Yixiao Xiong, Yuxin Zhang, Huifang Liang, Kun Cheng, Yuanxiang Lu, Guangzhen Cai, Yang Wu, Yunhui Fan, Xiaoping Chen, Hong Zhu, Zeyang Ding, Wanguang Zhang   +12 more
wiley   +1 more source

Lipid metabolism reprograming by SREBP1‐PCSK9 targeting sensitizes pancreatic cancer to immunochemotherapy

Cancer Communications, EarlyView.
Abstract Background Pancreatic cancer's aberrant lipid metabolism fuels cell growth, invasion, and metastasis, yet its impact on immune surveillance and immunotherapy is unclear. This study investigated how sterol regulatory element‐binding transcription factor 1 (SREBP1)‐driven lipid metabolism affects the tumor microenvironment (TME) in pancreatic ...
Mengyi Lao, Xiaozhen Zhang, Zejun Li, Kang Sun, Hanshen Yang, Sicheng Wang, Lihong He, Yan Chen, Hanjia Zhang, Jiatao Shi, Daqian Xu, Tingbo Liang, Xueli Bai   +12 more
wiley   +1 more source

Development and validation of a predictive model for perioperative low-density lipoprotein as a risk factor for postoperative cerebral infarction in Moyamoya disease. [PDF]

Front Neurol
Wu J, Xu Y, Zhang C, Mu C, Yu L, Xu H, Wang C, Cui Z.   +7 more
europepmc   +1 more source

LC‐DAD‐MSn and HR‐LC‐QTOF Analysis of Ziziphus budhensis Leaves and Evaluation of Their In Vitro and In Vivo Biological Activities

Chemistry &Biodiversity, EarlyView.
ABSTRACT Ziziphus budhensis Bhattarai & M.L. Pathak is a specie described in 2015 in Nepal poorly studied for its phytochemical composition and possible bioactivities. In this study, six extracts were obtained from Z. budhensis leaves using ultrasound assisted extraction with solvents in increasing polarity namely hexane, dichloromethane, chloroform ...
Samjhana Bharati, Binita Maharjan, Timila Shrestha, Shyam Sharan Shrestha, Stefania Sut, Hari Prasad Devkota, Ram Lal Swagat Shrestha, Stefano Dall'Acqua   +7 more
wiley   +1 more source

Proteomic and lipidomic analysis of low-density lipoprotein identifies potential biomarkers of early estrogen receptor-positive breast cancer. [PDF]

Cancer Metab
Abu Mohsen Y, Twitto-Greenberg R, Cohen A, Leichner GS, Mahler L, Cohen H, Kamari Y, Shaish A, Harari A, Leikin-Frenkel A, Glick Saar E, Geiger T, Malitsky S, Itkin M, Harats D, Keshet R.   +15 more
europepmc   +1 more source

Promising Prodiginins Biological Activities

Chemistry &Biodiversity, EarlyView.
ABSTRACT Prodiginins are a large family of at least 34 pyrrolic compounds, including the well‐studied red pigment prodigiosin. Prodiginins are produced by several microorganisms displaying broad biological activities, including antimicrobial, antiviral, antiparasitic, antiproliferative, and immunosuppressive activities.
María F. Ladetto, Melisa E. Gantner, Boris E. Rodenak‐Kladniew, Santiago Rodriguez, María L. Cuestas, Alan Talevi, Guillermo R. Castro   +6 more
wiley   +1 more source

Suboptimal Control of Small Dense Low-Density Lipoprotein Cholesterol Is Associated With Coronary Plaque Progression: An Intravascular Ultrasound Study. [PDF]

J Am Heart Assoc
Amuti A, Li YR, Yuan H, Feng S, Tay GP, Tang SY, Wu XR, Tao LY, Lu L, Zhang RY, Yang CD, Wang XQ.   +11 more
europepmc   +1 more source

The Phenolic Content and Bioactivity Assessment of Rubus sanctus Schreber Species with Potential for Food and Ethnopharmacological Uses

Chemistry &Biodiversity, EarlyView.
ABSTRACT In this study, the phytochemical content and various biological activities of Rubus sanctus Schreber species, widely distributed in Turkiye and used in folk medicine, were determined. The ethanol extracts of the root and aerial parts of the species were prepared and their bioactive phytochemical composition was identified by liquid ...
Ismail Yener
wiley   +1 more source

Comprehensive Mendelian randomization analysis of low-density lipoprotein cholesterol and multiple cancers. [PDF]

Discov Oncol
Liang H, Tang C, Sun Y, Wang M, Tong T, Gao Q, Xie H, Tan T.   +7 more
europepmc   +1 more source

Ethnomedicinal Uses, Phytochemistry, Pharmacological Activities, and Toxicology of the Subfamily Gomphrenoideae (Amaranthaceae): A Comprehensive Review

Chemistry &Biodiversity, EarlyView.
ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves, Giulia Cristina de Andreoli Souza, Alvaro Jose Hernandez Tasco, Marcos José Salvador   +3 more
wiley   +1 more source