Results 351 to 360 of about 1,439,975 (404)

Low-density lipoprotein and oxidised low-density lipoprotein: Their role in the development of atherosclerosis

Pharmacology & Therapeutics, 1997
Oxidation of low-density lipoprotein (LDL) may be implicated in the development of atherosclerotic disease. Oxidised LDL is taken up more readily by monocyte-derived macrophages than LDL. Antibodies to oxidised LDL are found in atherosclerotic lesions, Increased risk of ischaemic heart disease is associated with a preponderance of small dense LDL ...
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Receptors for modified low-density lipoproteins on human endothelial cells: different recognition for acetylated low-density lipoprotein and oxidized low-density lipoprotein

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1991
We examined the uptake pathway of acetylated low-density lipoprotein and oxidatively modified LDL (oxidized LDL) in human umbilical vein endothelial cells in culture. Proteolytic degradation of 125I-labeled Ac-LDL or Ox-LDL in the confluent monolayer of human endothelial cells was time-dependent and showed saturation kinetics in the dose-response ...
Hidenori Arai, Noriaki Kume, Chuichi Kawai, Toru Kita   +3 more
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Immunity to Low-Density Lipoprotein [PDF]

, 2011
Animal experiments, epidemiological studies and clinical investigations all show that high levels of plasma low-density lipoprotein (LDL) promote atherosclerotic cardiovascular disease [1]. LDL particles contain epitopes that trigger cellular and humoral immune responses. Autoimmunization during the course of atherosclerosis generates proinflammatory T
Göran K. Hansson, Göran K. Hansson
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Low-density Lipoproteins in Atherogenesis

2000
It is well established that high levels of plasma cholesterol, particularly those associated with low-density lipoprotein (LDL), increase the risk of developing atherosclerosis. It is also clear that lowering plasma cholesterol levels can arrest or even reverse the progression of the disease [1,2].
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Low-Density Lipoprotein Receptor-Related Proteins

Encyclopedia of Molecular Pharmacology, 2021
M. Narita, David M Holtzman, Alan, L., Schwartz, G. Bu   +5 more
semanticscholar   +1 more source

Low-density lipoprotein oxidation.

Italian heart journal : official journal of the Italian Federation of Cardiology, 2001
Free radical mediated oxidation of low-density lipoproteins (LDL), which has been extensively studied in the last two decades, plays a central role in the development of the atherosclerotic plaque. Oxidation involves the lipid moiety of LDL in a chain reaction mechanism.
IULIANO, Luigi, MICHELETTA F, VIOLI, Francesco   +2 more
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Low density lipoprotein turnover in swine

Canadian Journal of Biochemistry, 1978
The catabolism of intravenously injected 125I-labelled low density lipoproteins (LDL) was followed in normal miniature swine for 2 weeks. When compared with the two-exponential model, the decay curve of the plasma radioactivity associated with the LDL fraction was best described by a three-exponential model. In this system, the half-lives were 4.5 ± 3.
Y.L. Marcel, W. T. Robinson, D. Jeffries, M. Bidallier, M. Bergseth, A.C. Nestruck   +5 more
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Small, dense low-density lipoprotein particles as a predictor of the risk of ischemic heart disease in men. Prospective results from the Québec Cardiovascular Study.

Circulation, 1997
BACKGROUND Case-control studies have reported that patients with ischemic heart disease (IHD) have a higher proportion of small, dense LDL particles than do healthy control subjects.
Benoicirct Lamarche, A. Tchernof, S. Moorjani, B. Cantin, G. Dagenais, P. Lupien, J. Despre´s   +6 more
semanticscholar   +1 more source

Is directly measured low-density lipoprotein clinically equivalent to calculated low-density lipoprotein?

Journal of Clinical Lipidology, 2010
Low-density lipoprotein cholesterol (LDL-C) can either be calculated or measured directly. Clinical guidelines recommend the use of calculated LDL-C (C-LDL-C) to guide therapy because the evidence base for cholesterol management is derived almost exclusively from trials that use C-LDL-C, with direct measurement of LDL-C (D-LDL-C) being reserved for ...
Swapna Johnson, Bhanu Gupta, Katelyn Kelly-Johnson, Lawrence Baruch, Lawrence Baruch, Calvin Eng, Calvin Eng, Ann F. Haynos, Sanjay Agarwal   +8 more
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Low Density Lipoprotein Apheresis

2013
Therapeutic plasma exchange volume is usually 3–5 L/session. Removal of positively charged particles as well as low density lipoprotein cholesterol improves focal segmental glomerulosclerosis and peripheral arterial disease. Angiotensin converting enzyme (ACE) inhibitors should be discontinued at least 2–3 days prior to low density ...
Kent Doi, Kenjiro Honda
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