Results 281 to 290 of about 601,516 (329)

Impact of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors on intracranial atherosclerotic plaque characteristics and low density lipoprotein-cholesterol (LDL-C) reduction: a real-world observational study. [PDF]

PeerJ
Li Z, Li X, Zhang Y, Qi J, Ji L, Li S, Gu M, Liu Y, Zhang Y, Mei Y, Wang M, Zhou J, Su M, Zhu L, Deng Q.   +14 more
europepmc   +1 more source

Therapeutic Gene Editing: DNA Repair Pathways, Emerging Editors, and Clinical Progress

iNew Medicine, EarlyView.
ABSTRACT The field of gene editing has evolved rapidly over the past decade, progressing from programmable zinc‐finger nucleases (ZFNs) and transcription activator‐like effector nucleases (TALENs) to the widespread adoption of CRISPR‐Cas systems. First‐generation editors catalyzed genome engineering by introducing targeted double‐strand breaks (DSBs ...
Li‐Kuang Tsai, Youcai Xiong, Dongqi Liu, Dongshan Yang, Jifeng Zhang, Jie Xu, Renzhi Han, Y. Eugene Chen   +7 more
wiley   +1 more source

Long-Term Exposure to High Low-Density Lipoprotein Cholesterol Levels and Clinical Course in Secondary Prevention After Coronary Artery Disease. [PDF]

Circ Rep
Matsumoto I, Mukaida K, Wada K, Kurozumi M, Namba T, Takagi Y.   +5 more
europepmc   +1 more source

Socioeconomic Status Modifies the Risk of Gastric Cancer Through Metabolomic Signature: Evidence From a Prospective Cohort Study

iNew Medicine, EarlyView.
ABSTRACT The role of metabolites in the association between socioeconomic status (SES) and gastric cancer remains unclear. This study seeks to elucidate the role of metabolomics in the association between SES and gastric cancer, as well as to explore potential interactions between metabolic signatures and polygenic risk score (PRS) in the context of ...
Shiyin Meng, Shangxin Zhang, Jing Wang, Zhuoyi Wu, Wenjie Xuan, Jiawei Zhang, Qihong Zhao, Anla Hu, Jing Ni   +8 more
wiley   +1 more source

Low-Density Lipoprotein Cholesterol Levels and Bleeding Risk in Venous Thromboembolism.

JAMA Netw Open
Siniscalchi C, Meschi T, Di Micco P, Imbalzano E, Hernández-Blasco L, Mahé I, Fernández-Reyes JL, García-Ortega A, Verhamme P, Alfonso-Megido J, Monreal M, RIETE Investigators.   +11 more
europepmc   +1 more source

Decrease in low-density lipoprotein cholesterol is associated with an increased risk of mortality in patients with diabetes mellitus. [PDF]

Front Cardiovasc Med
Kim YG, Jeong JH, Han KD, Roh SY, Seo CO, Kim Y, Lee HS, Shim J, Kim YH, Choi JI.   +9 more
europepmc   +1 more source

Adipose‐derived small extracellular vesicles exacerbate microvascular dysfunction in heart failure with preserved ejection fraction via mmu‐miR‐582‐3p‐mediated Rap1b suppression

Interdisciplinary Medicine, EarlyView.
This study reveals that small extracellular vesicles (sEVs) from visceral fat compromise coronary microcirculation in a mouse model of heart failure with preserved ejection fraction (HFpEF). The SGLT2 inhibitor canagliflozin emerges as a therapeutic strategy, improving cardiac function and endothelial health.
Lu Chen, Qiuhan Wang, Mengjia Shen, Mingjue Li, Yingqi Zhu, Cankun Zheng, Siyuan Ma, Hairuo Lin, Xiaokang Fu, Rui Zhang, Jianping Bin, Yulin Liao, Qiancheng Wang   +12 more
wiley   +1 more source

Low-Density Lipoprotein Cholesterol Reduction and Therapeutic Adherence During Cardiac Rehabilitation After Myocardial Infarction. [PDF]

J Clin Med
Bertolín-Boronat C, Merenciano-González H, Marcos-Garcés V, Martínez Mas ML, Climent Alberola JI, Civera JM, Valls Reig M, Ruiz Hueso M, Castro Carmona P, Perez N, López-Bueno L, Díaz Díaz B, Miñano Martínez I, Payá Rubio A, Ríos-Navarro C, de Dios E, Gavara J, Jiménez-Navarro MF, Sanchis J, Bodi V.   +19 more
europepmc   +1 more source

Exploring Uric Acid to HDL Ratio as a Long‐Term Biomarker for Diabetes Mellitus

Journal of Clinical Laboratory Analysis, EarlyView.
This study explores the predictive value of the serum uric acid to HDL cholesterol ratio (UHR) for diabetes mellitus (DM) using data from the decade‐long MASHAD cohort. Elevated UHR levels were significantly associated with increased DM risk, with gender‐specific thresholds identified through ROC analysis. These findings support UHR as a promising long‐
Rana Kolahi, Reza Khademi, Mahboobeh Ghasemzadeh Rahbardar, Niloofar Shabani, Habibollah Esmaily, Nazanin Akbari, Reyhane Alizadeh, Malihehsadat Abedsaeidi, Sara Saffar Soflaei, Majid Ghayour‐Mobarhan   +9 more
wiley   +1 more source

Prognostic value of gut microbiota and low-density lipoprotein cholesterol subfractions in patients with ST-segment elevation myocardial infarction. [PDF]

Front Immunol
Xia S, Liu Y, Wang M, Liu D, Zhang X, Lin L, Wen M, Ji S, Li J, Zhang X, Jiang H.   +10 more
europepmc   +1 more source