Results 71 to 80 of about 14,760,056 (304)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Toughening epoxy resins with soluble hyperbranched poly (aryl ether ketone): enhanced mechanical properties and thermal stability

Advanced Manufacturing: Polymer & Composites Science
The limited toughness of epoxy resins (EP) significantly hinders their application. While hyperbranched polymers are commonly employed as toughening agents, their poor solubility often leads to drawbacks, including a marked reduction in glass transition ...
Xiyan Li, Feng Bao, Shuang’er Li, Tang Zhu, Jiali Yu, Qing Zhang, Huichao Liu, Caizhen Zhu, Jian Xu   +8 more
doaj   +1 more source

Stability of low-dimensional materials as novel supports in electrocatalysis

, 2023
In recent years, there has been a significant rise in research done to discover various novel support materials in electrocatalysis, with one of the most relevant applications being fuel cells. Promising support materials are low-dimensional carbon-based
Nurul Hany Binte Mohammed Roslie
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Optimization Design of Fluoro‐Cyanogen Copolymer Electrolyte to Achieve 4.7 V High‐Voltage Solid Lithium Metal Battery

Advanced Science
Raising the charging voltage and employing high‐capacity cathodes like lithium cobalt oxide (LCO) are efficient strategies to expand battery capacity. High voltage, however, will reveal major issues such as the electrolyte's low interface stability and ...
Weijian Xu, Weiliang Dong, Jianzhou Lin, Kexin Mu, Zhennuo Song, Jiji Tan, Ruixue Wang, Qiang Liu, Caizhen Zhu, Jian Xu, Lei Tian   +10 more
doaj   +1 more source

Dielectric material options for integrated capacitors [PDF]

, 2014
Future MIM capacitor generations will require significantly increased specific capacitances by utilization of high-k dielectric materials. In order to achieve high capacitance per chip area, these dielectrics have to be deposited in three-dimensional ...
Halimaou, A, Kessels, WMM Erwin, Zauner, A., Roozeboom, F Fred, Langereis, E., Haukka, S., Lukosius, M, Roozeboom, F., Rushworth, S.A., Haukka, S, Riou, B, Blomberg, T, Lehnert, W., Besling, WFA, Lhostis, S, Baristiran Kaynak, C., Blomberg, T., Besling, W.F.A., Ruhl, G, Wenger, C., Riou, B., Baumann, P.K., Roest, A.L., Halimaou, A., Langereis, E Erik, Rushworth, SA, Lukosius, M., Lehnert, W, Zauner, A, Ruhl, G., Wenger, C, Baristiran Kaynak, C, Lhostis, S., Baumann, PK, Kessels, W.M.M., Roest, AL   +35 more
core   +2 more sources

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Anisotropically biaxial strain in non-polar (112–0) plane In x Ga1−x N/GaN layers investigated by X-ray reciprocal space mapping

Scientific Reports, 2017
In this study, the indium composition x as well as the anisotropically biaxial strain in non-polar a-plane In x Ga1−x N on GaN is studied by X-ray diffraction (XRD) analysis. In accordance with XRD reciprocal lattice space mapping, with increasing indium
Guijuan Zhao, Huijie Li, Lianshan Wang, Yulin Meng, Zesheng Ji, Fangzheng Li, Hongyuan Wei, Shaoyan Yang, Zhanguo Wang   +8 more
doaj   +1 more source