Results 31 to 40 of about 115,982 (303)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Self-organising low Earth orbit constellations for Earth observation [PDF]

, 2014
This paper presents a novel method of manipulating the spatial pattern of a fractionated micro-satellite constellation in Low Earth Orbit. The method developed allows satellites to manipulate the longitudinal position of their ground-tracks over the ...
McInnes, Colin, Mushet, Garrie
core  

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

An aerostable drag-sail device for the deorbit and disposal of sub-tonne, low earth orbit spacecraft [PDF]

, 2006
There is an increasing amount of debris in low Earth orbit arising from the disintegration and collision of old spacecraft which have not been removed from orbit. A ‘bolt-on’ deorbit device to be attached to new spacecraft is therefore proposed, which
Harkness, Patrick George
core  

Rarefied gas effects on the aerodynamics of high area-to-mass ratio spacecraft in orbit [PDF]

, 2013
The aerodynamic situation of a satellite-on-a-chip operating in low Earth orbit bears some resemblance to a classical Crookes radiometer. The large area-to-mass ratio characteristic of a SpaceChip means that very small surface-dependent forces produce ...
Reese, Jason M., White, Craig, Colombo, Camilla, Scanlon, Thomas J., McInnes, Colin, Scanlon, Thomas, Reese, Jason, McInnes, Colin R.   +7 more
core   +1 more source

Handover Solutions for 5G Low-Earth Orbit Satellite Networks

IEEE Access, 2022
Low-Earth orbit (LEO) satellite networks are meant to be fundamental to closing the digital divide, enabling new market opportunities and providing fifth-generation (5G) New Radio (NR) connectivity everywhere at any time.
Enric Juan, Mads Lauridsen, Jeroen Wigard, Preben Mogensen   +3 more
doaj   +1 more source

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown, Giulia Carli, Prabesh Kanel, Stiven Roytman, Jaimie Barr, Nicolaas I. Bohnen, Roger L. Albin   +6 more
wiley   +1 more source

First In-orbit Experience of TerraSAR-X Flight Dynamics Operations [PDF]

, 2007
TerraSAR-X is an advanced synthetic aperture radar satellite system for scientific and commercial applications that is realized in a public-private partnership between the German Aerospace Center (DLR) and the Astrium GmbH.
Kiehling, Reinhard, Kirschner, M., Kazeminejad, Bobby, Kiehling, R., Yoon, Y., Kirschner, Michael, Kahle, Ralph, D'Amico, Simone, D'Amico, S., Kahle, R., Kazeminejad, B., Yoon, Yoke   +11 more
core   +1 more source

Analytical model for the propagation of small debris objects clouds after fragmentations [PDF]

, 2015
Current debris evolutionary models usually neglect fragments smaller than 10 cm because of the high computational effort they add to the simulation. However, small-debris objects can also be dangerous to operational satellites.
Colombo, Camilla, Lewis, Hugh G.; id_orcid, Letizia, Francesca, Lewis, Hugh G.   +3 more
core   +1 more source