Results 231 to 240 of about 2,502,976 (307)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Extracorporeal and Conventional Cardiopulmonary Resuscitation and Low-Flow Duration: Insights From a Nationwide Hospital-Based Registry Study in Japan (JAAM-OHCA Registry). [PDF]

J Am Heart Assoc
Matsuyama T, Ohta B, Komukai S, Cheskes S, Lin S, Mohindra R, Drennan I, von Vopelius-Feldt J, Kitamura T.   +8 more
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Outcomes of surgical versus transcatheter aortic valve replacement in patients with low-flow, low-gradient aortic stenosis. [PDF]

J Thorac Cardiovasc Surg
Brown JA, Ashwat E, Warraich N, Iyanna N, Serna-Gallegos D, Kliner D, Toma C, West D, Makani A, Hasan I, Ogami T, Ahmad D, Thoma F, Wang Y, Sultan I.   +14 more
europepmc   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Early Stroke Volume Variation After Transcatheter or Surgical Aortic Valve Replacement Predicts Clinical Outcomes in Low-Flow Aortic Stenosis. [PDF]

Catheter Cardiovasc Interv
Fiore G, Biondi F, Cunsolo P, Morosato M, Gamardella M, Ingallina G, Stella S, Ancona F, Tavernese A, Margonato D, Fabris M, Castiglioni A, Montorfano M, Maisano F, Agricola E.   +14 more
europepmc   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Improving the hemocompatibility of centrifugal mechanical circulatory support devices at low flow rates. [PDF]

Artif Organs
Specklin M, Marcel L, Abbasnezhad N, Bakir F, Kouidri S, Danial P.   +5 more
europepmc   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Outcomes and Predictors of Flow Improvement After Transcatheter Aortic Valve Replacement in Patients With Low-Flow Low-Gradient Aortic Stenosis. [PDF]

Struct Heart
Besir B, Ali Majeed-Saidan MM, Ramu SK, Lomaia T, Rajendran J, Iskandar O, Motairek I, Harb SC, Miyasaka R, Yun J, Puri R, Reed GW, Krishnaswamy A, Kapadia SR.   +13 more
europepmc   +1 more source