Results 51 to 60 of about 11,576,054 (206)

Mechanisms underlying low flow-low gradient aortic stenosis

, 2022
Aortic stenosis (AS) remains the most common valvular disease in the elderly with an increasing prevalence, owing to the predominance of degenerative etiologies; hence, represents a major public health burden. The majority of patients with severe AS exhibit normal flow across the aortic valve and high transvalvular mean gradient (ΔPm), those patients ...
El Kenani, Manar, Katschinski, Dörthe, Katschinski, Dörthe, Georg-August-Universität Göttingen, Zimmermann, Wolfram-Hubertus, Thoms, Sven   +5 more
openaire   +2 more sources

Predictors of Mortality and Symptomatic Outcome of Patients With Low‐Flow Severe Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundImpaired left ventricular (LV) ejection fraction is a common finding in patients with aortic stenosis and serves as a predictor of morbidity and mortality after transcatheter aortic valve replacement.
Norman Mangner, Georg Stachel, Felix Woitek, Stephan Haussig, Florian Schlotter, Robert Höllriegel, Jennifer Adam, Anna Lindner, Friedrich W. Mohr, Gerhard Schuler, Philipp Kiefer, Sergey Leontyev, Michael A. Borger, Holger Thiele, David Holzhey, Axel Linke   +15 more
doaj   +1 more source

Comprehensive assessment of the aortic valve in critically ill patients for the non-cardiologist. Part I: Aortic stenosis of the native valve

Anaesthesiology Intensive Therapy, 2021
Aortic stenosis (AS) causes left ventricular outflow obstruction. Severe AS has major haemodynamic implications in critically ill patients, in whom increased cardiac output and oxygen delivery are often required.
Jeroen Walpot, Guy L. Vermeiren, Amar Al Mafragi, Manu L.N.G. Malbrain   +3 more
doaj   +1 more source

Neural Fields for Highly Accelerated 2D Cine Phase Contrast MRI

Advanced Science, EarlyView.
ABSTRACT 2D cine phase contrast (CPC) MRI provides quantitative information on blood velocity and flow within the human vasculature. However, data acquisition is time‐consuming, motivating the reconstruction of the velocity field from undersampled measurements to reduce scan times. In this work, neural fields are proposed as a continuous spatiotemporal
Pablo Arratia, Martin J. Graves, Mary McLean, Carolin Pirkl, Carola‐Bibiane Schönlieb, Timo Schirmer, Florian Wiesinger, Matthias J. Ehrhardt   +7 more
wiley   +1 more source

Interdisciplinary three-step strategy to treat aortic stenosis and coronary artery disease in a patient with end-stage chronic obstructive pulmonary disease [PDF]

, 2012
Background: Valvular aortic stenosis is a common disease in the elderly, often in multimorbid patients. It is often associated with coronary artery disease and peripheral artery disease.
Michel, Sebastian, Schmitz, Christoph, Kaczmarek, Ingo, Sodian, Ralf, Wolf, Manuel, Bigdeli, Amir Khosrow, Beiras Fernández, Andrés   +6 more
core   +1 more source

Left Ventricular Mechanics Differ in Subtypes of Aortic Stenosis Following Transcatheter Aortic Valve Replacement

Frontiers in Cardiovascular Medicine, 2022
BackgroundLeft ventricular (LV) mechanics are impaired in patients with severe aortic stenosis (AS). We hypothesized that there would be differences in myocardial mechanics, measured by global longitudinal strain (GLS) recovery in patients with four ...
Adil Wani, Daniel R. Harland, Tanvir K. Bajwa, Stacie Kroboth, Khawaja Afzal Ammar, Suhail Q. Allaqaband, Sue Duval, Bijoy K. Khandheria, A. Jamil Tajik, Renuka Jain   +9 more
doaj   +1 more source

Cardiac resynchronization therapy in low-flow low-gradient aortic stenosis. [PDF]

Eur Heart J Cardiovasc Imaging, 2016
A 74-year-old male with New York Heart Association (NYHA) Class IV heart failure, low-flow low-gradient (LFLG) aortic stenosis, and severe functional mitral regurgitation (MR) was referred for transcatheter aortic valve implantation. Medical history included permanent atrial fibrillation and complete heart block requiring dual-chamber pacemaker ...
Goel K, Noseworthy PA, Asirvatham SJ, Nkomo VT.   +3 more
europepmc   +3 more sources

KLF5 Downregulation Links Impaired BNIP3‐Mediated Mitophagy to Inflammatory Valve Remodeling in Calcific Aortic Valve Disease

Advanced Science, EarlyView.
In human CAVD, KLF5 is reduced in VIC‐rich regions and remodeling/stress‐associated VIC states. In VICs, KLF5 sustains BNIP3 promoter activity and BNIP3‐mediated mitophagy, thereby limiting cytosolic mtDNA accumulation. KLF5 loss weakens mitochondrial quality control and enhances mtDNA‐sensitive STING/NF‐κB/NLRP3 inflammatory signaling under osteogenic
Jin‐Hui Bian, Jia‐Xi Gu, Zhang Yue, Chun‐Ze Yuan, Hai‐Bin Ji, Ao Li, Yu Zhong, Xiu‐Fan Xu, Yu‐Qiu He, Ye‐Fan Jiang, Hong‐Shan Chen, Xiang Chen, Meng‐Lin Chao, Yong‐Feng Shao   +13 more
wiley   +1 more source

LES of additive and non-additive pulsatile flows in a model arterial stenosis [PDF]

, 2010
Transition of additive and non-additive pulsatile flows through a simple 3D model of arterial stenosis is investigated by using a large eddy simulation (LES) technique. We find in both the pulsatile cases that the interaction of the two shear layers, one
Molla, M.M., Roditi, G., Paul, M.
core   +1 more source

Proof of concept study on coronary microvascular function in low flow low gradient aortic stenosis [PDF]

, 2022
ObjectivesWe hypothesised that low flow low gradient aortic stenosis (LFLGAS) is associated with more severe coronary microvascular dysfunction (CMD) compared with normal-flow high-gradient aortic stenosis (NFHGAS) and that CMD is related to reduced ...
Scarsini, Roberto, Roberto Scarsini, Giovanni Benfari, Gabriele Pesarini, Springhetti, Paolo, Gottin, Leonardo, Flavio Luciano Ribichini, Pesarini, Gabriele, Andrea Mainardi, Benfari, Giovanni, Bergamini, Corinna, Ribichini, Flavio Luciano, Corinna Bergamini, Tavella, Domenico, Francesco Della Mora, Concetta Mammone, Leonardo Gottin, Pighi, Michele, Della Mora, Francesco, Leonardo Portolan, Fanti, Diego, Mainardi, Andrea, Paolo Springhetti, Domenico Tavella, Portolan, Leonardo, Michele Pighi, Mammone, Concetta, Diego Fanti   +27 more
core   +1 more source