Results 61 to 70 of about 11,582,841 (294)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Charge noise and spin noise in a semiconductor quantum device [PDF]

, 2014
Self-assembled quantum dots are very attractive as the building blocks for quantum light sources and spin qubits. For instance, a single quantum dot is a robust, fast, narrow-linewidth source of single photons, features not shared by any other ...
Kuhlmann, Andreas V.
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Low-Frequency Noise Spectroscopy of Low-Dimensional Layered Materials

Crystals
Two-dimensional (2D) layered materials—graphene, hexagonal boron nitride (hBN), transition metal dichalcogenides (TMDs), and layered van der Waals (vdW) thiophosphates—constitute a rapidly expanding family whose properties are governed by weak van der ...
Ilona Zamaraite, Andrius Dziaugys, Juras Banys   +2 more
doaj   +1 more source

Study and Assessment of Low Frequency Noise in Occupational Settings

Archives of Acoustics, 2015
Low frequency noise is one of the most harmful factors occurring in human working and living environment. Low frequency noise components from 20 to 250 Hz are often the cause of employee complaints.
Adel M. SHEHAP, Hany A. SHAWKY, Tarek M. EL-BASHEER   +2 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Low Frequency Noise and phantom sounds

Noise Notes, 2009
Suffering from more or less continuous and more or less steady low pitched sounds at home can be a serious threat to well-being. Often the sound source is not obvious or cannot be found. In many cases there is no clear evidence from the analysis of the ambient sound what the disturbing sound could be.
openaire   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Evaluation of annoyance from low frequency noise under laboratory conditions

Noise and Health, 2010
The aim of the study was to investigate the annoyance of low frequency noise (LFN) at levels normally prevailing at workplaces in control rooms and office-like areas. Two different laboratory experiments were carried out. The first experiment included 55
Malgorzata Pawlaczyk-Luszczynska, Adam Dudarewicz, Wieslaw Szymczak, Mariola Sliwinska-Kowalska   +3 more
doaj   +1 more source