Results 101 to 110 of about 21,901,458 (195)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

NRGS-Net: A Lightweight Uformer with Gated Positional and Local Context Attention for Nighttime Road Glare Suppression

Applied Sciences
Existing nighttime visibility enhancement methods primarily focus on improving overall brightness under low-light conditions. However, nighttime road images are also affected by glare, glow, and flare from complex light sources such as streetlights and ...
Ruoyu Yang, Huaixin Chen, Sijie Luo, Zhixi Wang   +3 more
doaj   +1 more source

Query by low-quality image

, 2009
The motivation for research on low-quality images comes from a requirement by some museums to respond to queries for pictorial information, submitted in the form of fax messages or other low-quality monochrome images of works of art.
Fauzi, Mohammad Faizal Ahmad, Lewis, Paul H.   +1 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Low-light Image Enhancement via Multispectral Reconstruction

Low-light images often fail to accurately capture color and texture, limiting their practical applications in imaging technology. The use of low-light image enhancement technology can effectively restore the color and texture information contained in the
Xin, L., Luo, H., Hu, X., Liang, J., Xiao, K., Ma, X.   +5 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Low-Light Image Enhancement Based on Optimized Semantic Contrastive Learning Application in Orchards

Horticulturae
Low-light conditions in orchards and facility agriculture hinder accurate fruit recognition. To enhance efficiency in such environments, an optimized semantic contrastive learning-based nighttime fruit image enhancement model, OSCL (Optimized Semantic ...
Tong Guo, Zhifen Wang, Kangwen Wang, Chengzhi Ruan, Xiude Chen, Weikuan Jia   +5 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

DCTE-LLIE: A Dual Color-and-Texture-Enhancement-Based Method for Low-Light Image Enhancement

Computers
The enhancement of images captured under low-light conditions plays a vitally important role in the area of image processing and can significantly affect the performance of following operations.
Hua Wang, Jianzhong Cao, Lei Yang, Jijiang Huang   +3 more
doaj   +1 more source