Results 61 to 70 of about 157,053 (258)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Low-Light Image Enhancement by Principal Component Analysis

IEEE Access, 2019
Under extreme low-lighting conditions, images have low contrast, low brightness, and high noise. In this paper, we propose a principal component analysis framework to enhance low-light-level images with decomposed luminance–chrominance components.
Steffi Agino Priyanka, Yuan-Kai Wang, Shih-Yu Huang   +2 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Non-linear Low-Light Image Enhancement Based on Fusion Color Model Space

四川大学学报. 自然科学版, 2021
Lowlight images have problems such as low overall brightness of the image, uneven brightness, high color saturation, and image blur. To address these problems, a lowlight image enhancement algorithm fusing color model space is proposed, in which the ...
LIU Shou-Xin, LONG Wei, LI Yan-Yan, CHENG Hong   +3 more
doaj  

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

A Dual-Branch Autoencoder Network for Underwater Low-Light Polarized Image Enhancement

Remote Sensing
Underwater detection faces uncomfortable illumination conditions, and traditional optical images sensitive to intensity often cannot work well in these conditions.
Chang Xue, Qingyu Liu, Yifan Huang, En Cheng, Fei Yuan   +4 more
doaj   +1 more source

Low-Light Image Enhancement Method Based on Retinex Theory by Improving Illumination Map

Applied Sciences, 2022
Recently, low-light image enhancement has attracted much attention. However, some problems still exist. For instance, sometimes dark regions are not fully improved, but bright regions near the light source or auxiliary light source are overexposed.
Xinxin Pan, Changli Li, Zhigeng Pan, Jingwen Yan, Shiqiang Tang, Xinghui Yin   +5 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source