Results 71 to 80 of about 22,853,467 (283)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Low-Light Image Enhancement by Principal Component Analysis

IEEE Access, 2019
Under extreme low-lighting conditions, images have low contrast, low brightness, and high noise. In this paper, we propose a principal component analysis framework to enhance low-light-level images with decomposed luminance–chrominance components.
Steffi Agino Priyanka, Yuan-Kai Wang, Shih-Yu Huang   +2 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

A Dual-Branch Autoencoder Network for Underwater Low-Light Polarized Image Enhancement

Remote Sensing
Underwater detection faces uncomfortable illumination conditions, and traditional optical images sensitive to intensity often cannot work well in these conditions.
Chang Xue, Qingyu Liu, Yifan Huang, En Cheng, Fei Yuan   +4 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Low-Light Image Enhancement Method Based on Retinex Theory by Improving Illumination Map

Applied Sciences, 2022
Recently, low-light image enhancement has attracted much attention. However, some problems still exist. For instance, sometimes dark regions are not fully improved, but bright regions near the light source or auxiliary light source are overexposed.
Xinxin Pan, Changli Li, Zhigeng Pan, Jingwen Yan, Shiqiang Tang, Xinghui Yin   +5 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Unsupervised Boosted Fusion Network for Single Low-Light Image Enhancement

IEEE Access
Unsupervised methods are gradually becoming a research hotspot in low-light image enhancement due to their lack of paired training data and higher quality visual enhancement effects, but existing unsupervised low-light image enhancement methods generate ...
Jianfeng Zhang, Hengxuan Li, Zhanqiang Huo   +2 more
doaj   +1 more source

Non-linear Low-Light Image Enhancement Based on Fusion Color Model Space

四川大学学报. 自然科学版, 2021
Lowlight images have problems such as low overall brightness of the image, uneven brightness, high color saturation, and image blur. To address these problems, a lowlight image enhancement algorithm fusing color model space is proposed, in which the ...
LIU Shou-Xin, LONG Wei, LI Yan-Yan, CHENG Hong   +3 more
doaj