Results 41 to 50 of about 81,809 (301)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Low-noise photodiode-amplifier circuit

IEEE Journal of Solid-State Circuits, 1994
A photodiode-amplifier circuit with the photodiode in the feedback path is presented. It is named the PIF-circuit. No resistor is needed at the amplifier input to provide a path to ground for the signal and leakage currents from the photodiode and the amplifier input bias current. Therefore, one potentially dominating noise source is eliminated.
Hyyppä, Kalevi, Ericson, Klas
openaire   +3 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Amplificador de baixo ruído CMOS porta comum para 2,4 GHZ [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia Elétrica, Florianópolis, 2009Este trabalho apresenta um projeto de um amplificador de baixo ruído (LNA - do inglês, Low Noise ...
Pereira, Maicon Deivid
core  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

On the Lower Bound to the Input and Output Mismatch of Conditionally Stable Linear Two-Ports

IEEE Journal of Microwaves, 2023
In the design of amplifier stages based on unconditionally stable linear active two-ports, the amplifier gain can be maximized through simultaneous conjugate matching with passive loads at the input and output ports.
Giovanni Ghione, Marco Pirola
doaj   +1 more source

Investigation of in-situ parameter control in novel semiconductor optical amplifiers [PDF]

, 2012
Fibre optic networks form the backbone of modern communications systems. As demand for ever increasing bandwidth continues to grow, technologies that enable the expansion of optical networks will be the key to future development.
Carney, Kevin
core  

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Gm-boosted Flat Gain UWB Low Noise Amplifier with Noise Cancellation

Chemical Engineering Transactions, 2015
This paper presents a high power gain (S21) and low Noise Figure (NF) 3.1-10.6 GHz common gate (CG) CMOS ultra wideband (UWB) low noise amplifier (LNA) using active gm-boosted technology, T-match input network, self-body-bias, current reused and noise ...
X.R. Zhao, H.H. Fan, Z.J. Fu, F.Y. Ye, J.F. Chen   +4 more
doaj   +1 more source