Results 61 to 70 of about 874,804 (349)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Programmable low-voltage continuous-time filter for audio applications [PDF]

, 1999
The implementation of a continuous-time filter (CTF) useful for audio frequency applications is presented in this paper. The filter functions can be programmed and tuned with two independent control variables.
Rueda Rueda, Adoración, Yúfera García, Alberto   +1 more
core  

A filter synthesis technique applied to the design of multistage broad-band microwave amplifiers [PDF]

, 2002
A method for designing multistage broad-band amplifiers based upon well-known filter synthesis techniques is presented. Common all-pole low-pass approximations are used to synthesize prototype amplifier circuits that may be scaled in frequency and ...
Hunter, I., Parry, R., Pollard, R.D., Rooney, J.P.   +3 more
core   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Stable ac phase and amplitude comparator [PDF]

, 1967
Stable ac phase and amplitude comparator detects excessive vehicle maneuvering or vibration. It has phase demodulation, low-pass filter, and multiple threshold-setting capability designed specifically for low drifts over a wide range of ...
Bruce, H. P.
core   +1 more source

SiC multilayer photonic structures with self optical bias amplification [PDF]

, 2012
Characteristics of tunable wavelength pi'n/pin filters based on a-SiC:H multilayered stacked cells are studied both experimental and theoretically. Results show that the device combines the demultiplexing operation with the simultaneous photodetection ...
Barata, Manuel, Fantoni, Alessandro, Louro, Paula, Vaz da Silva, V, Vieira, Manuel Augusto, Vieira, Manuela   +5 more
core   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A Reconfigurable-Band Analog Filter Standard-Cell Based on Differential/Single Input Signaling

IEEE Access
This work presents a reconfigurable-band analog filter capable of performing the low-pass, high-pass, band-pass or all-pass functions. The proposed filter is a simple and compact cell composed of only two RC networks and one differential Operational ...
Alejandro Diaz-Sanchez, Gregorio Zamora-Mejia, Jose M. Rocha-Perez, Jose L. Vazquez-Gonzalez, Uriel G. Zapata-Rodriguez   +4 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source