Results 111 to 120 of about 14,353,564 (303)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

High-Performance Cu-Based Liquid Thermocells Enabled by Thermosensitive Crystallization and Etched Carbon Cloth Electrode

Nano-Micro Letters
Highlights A novel Cu+/Cu2+ redox couple was introduced to enable a thermosensitive crystallization process, significantly enhancing thermopower from 1.47 to 2.93 mV K‒1.
Wei Fang, Zeping Ou, Yifan Wang, Zhe Li, Qian Huang, Pengchi Zhang, Xinzhe Li, Yujie Zheng, Lijun Hu, Chen Li, Jianyong Ouyang, Kuan Sun   +11 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Power for Service

, 1944
Includes the history of the Puget Sound Power and Light Company power plants and ...
Puget Sound Power and Light Company
core  

Experimental study on the performance of micro gas turbines under different intake environments

Case Studies in Thermal Engineering
This article uses experimental methods to measure the operational performance and pollutant emissions of micro gas turbines in different intake environments, and analyzes the feasibility of replacing mine ventilation fans with micro gas turbines.
Liu Cong, Shi Zhijun, Li Yimin, Zhou Zhongning, Ma Lina   +4 more
doaj   +1 more source

Roadmap on low-power electronics

APL Materials
Table of ContentsI. BROAD OVERVIEW: .................................................................................................................................. 3A ROADMAP FOR LOW POWER COMPUTING: MATERIALS FOR A SUSTAINABLE MICROELECTRONICS FUTURE ..........
Ramamoorthy Ramesh, Sayeef Salahuddin, Suman Datta, Carlos H. Diaz, Dmitri E. Nikonov, Ian A. Young, Donhee Ham, Meng-Fan Chang, Win-San Khwa, Ashwin Sanjay Lele, Christian Binek, Yen-Lin Huang, Yuan-Chen Sun, Ying-Hao Chu, Bhagwati Prasad, Michael Hoffmann, Jia-Mian Hu, Zhi (Jackie) Yao, Laurent Bellaiche, Peng Wu, Jun Cai, Joerg Appenzeller, Supriyo Datta, Kerem Y. Camsari, Jaesuk Kwon, Jean Anne C. Incorvia, Inge Asselberghs, Florin Ciubotaru, Sebastien Couet, Christoph Adelmann, Yi Zheng, Aaron M. Lindenberg, Paul G. Evans, Peter Ercius, Iuliana P. Radu   +34 more
openaire   +5 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Power Minimisation Techniques for Testing Low Power VLSI Circuits (PhD Dissertation)

, 2000
Testing low power very large scale integrated (VLSI) circuits has recently become an area of concern due to yield and reliability problems. This dissertation focuses on minimising power dissipation during test application at logic level and register ...
Nicolici, N.
core   +1 more source

Application of Object Detection Algorithms in Non-Destructive Testing of Pressure Equipment: A Review

Sensors
Non-destructive testing (NDT) techniques play a crucial role in industrial production, aerospace, healthcare, and the inspection of special equipment, serving as an indispensable part of assessing the safety condition of pressure equipment.
Weihua Wang, Jiugong Chen, Gangsheng Han, Xiushan Shi, Gong Qian   +4 more
doaj   +1 more source