Results 141 to 150 of about 459,286 (299)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Industrial large model-based new energy equipment health state estimation method
Zhongguo Jianchuan YanjiuObjective To address the limitations of current health state estimation methods for naval vessel energy equipment, such as insufficient cross-device generalization ability and high model adaptation complexity, this study proposes a new energy equipment ...
Xinyi DONG +7 more
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Contextually Guided Transformers via Low-Rank Adaptation
Large Language Models (LLMs) based on Transformers excel at text processing, but their reliance on prompts for specialized behavior introduces computational overhead. We propose a modification to a Transformer architecture that eliminates the need for explicit prompts by learning to encode context into the model's weights.
Zhmoginov, Andrey +3 more
openaire +2 more sources
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
InformationAt present, generative AI has problems of insufficient content generation accuracy, weak personalized response, and low reasoning efficiency in adaptive learning scenarios, which limit its in-depth application in intelligent teaching.
Xuan Liu, Zhi Li
doaj +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
CoRA: Optimizing Low-Rank Adaptation with Common Subspace of Large Language Models [PDF]
Xiaojun Xiao +6 more
openalex +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Penrose Tiled Low-Rank Compression and Section-Wise Q&A Fine-Tuning: A General Framework for Domain-Specific Large Language Model Adaptation [PDF]
C.‐C. Jay Kuo +3 more
openalex +1 more source