Results 171 to 180 of about 9,716,149 (241)

Low-rank Adaptation for Spatio-Temporal Forecasting

Spatio-temporal forecasting is crucial in real-world dynamic systems, predicting future changes using historical data from diverse locations. Existing methods often prioritize the development of intricate neural networks to capture the complex ...
Chen, Wei, Li, Weichuang, Liu, Xu, Liang, Yuxuan, Ruan, Weilin, Dang, Xilin, Zhou, Jianxiang   +6 more
core  

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

PRILoRA: Pruned and Rank-Increasing Low-Rank Adaptation

With the proliferation of large pre-trained language models (PLMs), fine-tuning all model parameters becomes increasingly inefficient, particularly when dealing with numerous downstream tasks that entail substantial training and storage costs.
Benedek, Nadav, Wolf, Lior
core  

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Dynamic LoRA Fine-Tuning of DINOv3 for Multi-Component Pasture Biomass Estimation. [PDF]

Sensors (Basel)
Sen S, Dhankhar N, Bayat A.
europepmc   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Parameter-Efficient LoRA-GRL Adaptation for Cross-Center Classification of Benign and Malignant Lung Nodules on Heterogeneous Standard-Dose Chest CT: A Multi-Institutional Study from Palestine. [PDF]

J Imaging
Qasrawi R, AbuGhoush R, Issa G, Thwib S, Amro M, Al Taweel R, Asfour S, Dibas Y, Abukeshek T, Qubja M.   +9 more
europepmc   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Sensory adaptation and pupil-linked arousal support flexible evidence accumulation during perceptual decision making. [PDF]

Elife
McGaughey KD, Gold JI.
europepmc   +1 more source