Results 171 to 180 of about 173,284 (257)

Rethinking Low-Rank Adaptation in Vision: Exploring Head-Level Responsiveness across Diverse Tasks

Low-rank adaptation (LoRA) has shifted the paradigm of adapting pre-trained Vision Transformers (ViT), achieving great efficiency by updating only a subset of tailored parameters to approximate weight updates.
Zhou, Yao, Zhong, Yibo
core  

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

The BSRA framework for dual sparse parameter efficient fine tuning with block structured gating and rank adaptation. [PDF]

Sci Rep
Jian W, Chen G, Hong H, Zhang Y, Du C, Bao Z.   +5 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Spatial Adaptation of Primate Retinal Ganglion Cells Between Artificial and Natural Stimuli. [PDF]

eNeuro
Vystrčilová M, Sridhar S, Burg MF, Khani MH, Karamanlis D, Schreyer HM, Ramakrishna V, Krüppel S, Zapp SJ, Mietsch M, Gollisch T, Ecker AS.   +11 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Research on fine-tuning algorithms for Large Language Models integrating Uncertainty Modeling and External Memory Augmentation. [PDF]

PLoS One
Ma Y, Xing Y, Wu D, Zhou Y, Zi Y, Wang M, Deng Y, Pan S.   +7 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

OLORA+: A HYBRID APPROACH TO LOW-RANK ADAPTATION

This paper introduces and analyzes OLoRA+, a novel parameter-efficient fine-tuning method that enhances Low-Rank Adaptation (LoRA) by combining the orthonormal initialization of OLoRA with the differential learning rate optimization of LoRA+.
Kushmuratov Samariddin Ibodulla ugli, Davronov Rifkat Rakhimovich   +1 more
core  

Voice-Based Structured Nursing Documentation Using Automatic Speech Recognition and Large Language Models: Development and Evaluation Study. [PDF]

JMIR Nurs
Su MH, Wang WC, Hsu YM, Hou SY, Chuang SJ, Chang SS.   +5 more
europepmc   +1 more source