Results 171 to 180 of about 13,073,421 (310)

Supporting the Caregivers of Children With Developmental Disabilities in a Low-Resource Setting: What Are Their Needs? [PDF]

J Appl Res Intellect Disabil
Abeasi DA, Nkosi NG.
europepmc   +1 more source

Medical Concept Normalization in a Low-Resource Setting

CoRR
In the field of biomedical natural language processing, medical concept normalization is a crucial task for accurately mapping mentions of concepts to a large knowledge base. However, this task becomes even more challenging in low-resource settings, where limited data and resources are available.
openaire   +2 more sources

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Current Challenges in the Management of Sepsis in ICUs in Resource-Poor Settings and Suggestions for the Future

, 2019
Sepsis is a major cause of critical illness worldwide, especially in resource-poor settings. Intensive care units (ICUs) in low- and middle-income countries (LMICs) face many challenges that could affect patient outcome.
Kwizera, A, Dondorp, AM, Lubell, Y, Schultz, MJ, Adhikari, NKJ, Riviello, ED, Iyer, S, Dünser, MW, Papali, A, Pisani, L   +9 more
core  

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

Successful Empirical Treatment of a Severe Corneal Abscess After Delayed Consultation in a Low-Resource Setting: A Case Report. [PDF]

Clin Case Rep
Simba GN, Kulimushi FK, Iyimba CM, Murhega RB.   +3 more
europepmc   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

Modified Primary PSARP for an Adult Patient With Imperforate Anus With Rectoperineal Fistula in a Low-Resource Setting: Case Report. [PDF]

Case Rep Surg
Legesse AY, Teka H, Hafte M, Nyandemo S, Emil S.   +4 more
europepmc   +1 more source

Characterization of the key membrane protein cytochrome Cyc2 from Ghiorsea bivora

FEBS Open Bio, EarlyView.
This study reports the first detailed biochemical analysis of Cyc2TAG1_1, a cytochrome protein involved in microbial iron oxidation. We produced and purified this enzyme in E. coli, then measured its iron‐oxidizing efficiency, and characterized its electrical and structural properties.
Josiane Azizi, Alain Dolla, Frauke Baymann, Celine Rommevaux, Latifa Elantak, Helene Gaussier, Matthieu Nouailler   +6 more
wiley   +1 more source

Solitary neurocysticercosis mimicking tuberculoma and glioblastoma: A diagnostic challenge in a low-resource setting. [PDF]

Surg Neurol Int
Yousif ME, Mohamed FMA, Mohamed HMB.
europepmc   +1 more source