Results 111 to 120 of about 1,239,239 (274)
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Journal of Materials and Engineering Structures, 2023 In current study, Damage estimation is carried out using new methodology using parameters such as absorbed energy and degrading stiffness by pushover analysis. A new stiffness-based damage index is developed for each increasing step of pushover analysis,
Hemil Manharbhai CHAUHAN +1 more
doaj
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
, 2015 This project consists of a study of the flow around low-‐rise buildings and how it interacts along the surfaces. To study that, two techniques will be covered: oil technique and Computational Fluid Dynamics (CFD). It will give an overview of the oil technique, how to apply and its resolution and for CFD it will go through ...
openaire +2 more sources
Solar hot water system installed at Quality Inn, Key West, Florida [PDF]
The solar energy hot water system installed in the Quality Inn, Key West, Florida, which consists of four buildings is described. Three buildings are low-rise, two-story buildings containing 100 rooms.
core +1 more source
Influence of joint slippage on the seismic response of steel frames [PDF]
, 2005 The present paper presents an evaluation of the influence of joint slippage on the seismic response of steel frames. Using three alternative hysteretic joint models to simulate the connections of a representative low-rise steel frame, and a series of ...
Bento, Rita +2 more
core
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Experimental Study of Wind Pressures on Low-Rise H-Shaped Buildings
BuildingsRecognizing the urgent need for mitigating global warming, natural ventilation presents a potential strategy to reduce cooling energy demands, enhance thermal comfort, and contribute to indoor air quality.
Talita Andrioli Medinilha-Carvalho +4 more
doaj +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source