Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Development of a fragility model for low-rise steel and reinforced concrete buildings in Iran [PDF]
Numerical Methods in Civil EngineeringLow-rise buildings in Iran, especially in rural areas, include a significant part of the country''s total buildings. Considering this issue, along with the high level of seismicity of the country, and the need for decision-makers to develop effective ...
Ali Maghsoudi-barmi +1 more
doaj +1 more source
Designing the Malqaf for summer cooling in low-rise housing an experimental study [PDF]
, 2009 peer reviewedThe malqaf or windcatcher is Egyptian vernacular archetypal device that traps the wind into the building. For centuries, the malqaf has been used as a viable solution to ensure natural ventilation.
Attia, Shady, De Herde, André
core
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
SPACE-PLANNING DECISIONS OF LOW-RISE RESIDENTIAL BUILDINGS IN HOT CLIMATES
Вестник СибАДИ, 2017 This article describes the characteristic climatic features of the hot climate. Considered space planning solutions for low-rise residential buildings for areas with hot humid and hot dry climates.
M. V. Maksimova, S. O. Melnikova
doaj +1 more source
Putting the User First? A pioneering Scottish experiment in architectural research [PDF]
, 2008 This article traces the story of a unique Scottish experiment in Modernist architectural research in the 1950s, 1960s and 1970s: the Architecture Research Unit of Edinburgh University, one of the leaders in the UK's post-war efforts to expand the ...
Architecture +10 more
core +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Justification of the choice of wall material for low-rise construction [PDF]
E3S Web of ConferencesThe study analyzed the thermal performance of enclosing structures made of: polystyrene concrete, heat block, arbolite blocks, foam concrete and aerated concrete.
Dolmatov Sergey +6 more
doaj +1 more source
Mapping Europe into local climate zones [PDF]
, 2019 Cities are major drivers of environmental change at all scales and are especially at risk from the ensuing effects, which include poor air quality, flooding and heat waves.
Bechtel, Benjamin +3 more
core +2 more sources
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source