Results 91 to 100 of about 2,267,354 (370)

Seismic vulnerability: from building evaluation to a typology generalization [PDF]

, 2012
Outlining the best strategies for seismic risk mitigation requires that both benefits and costs of retrofitting are known in advance. The assessment of the vulnerability of building typologies is a first step of a more extensive effort, concerning the ...
Lamego, P., Lourenço, Paulo B., Sousa, M. L.   +2 more
core  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Beyond Power over Ethernet : the development of Digital Energy Networks for buildings [PDF]

, 2012
Alternating current power distribution using analogue control and safety devices has been the dominant process of power distribution within our buildings since the electricity industry began in the late 19th century.
Banks, Gerry, Counsell, John, Johnston, James, Stewart, Matt John   +3 more
core  

Effects of Orientations, Aspect Ratios, Pavement Materials and Vegetation Elements on Thermal Stress inside Typical Urban Canyons [PDF]

, 2019
The analysis of local climate conditions to test artificial urban boundaries and related climate hazards through modelling tools should become a common practice to inform public authorities about the benefits of planning alternatives. Different finishing
Acero, J.A., Fernandez, G., Laburu, T., Lobaccaro, G., Padro, A., Sanchez, G.   +5 more
core   +3 more sources

Explainable Machine Learning (XML) to predict external wind pressure of a low-rise building in urban-like settings

Journal of Wind Engineering and Industrial Aerodynamics, 2022
D. Meddage, I. Ekanayake, A. U. Weerasuriya, C. Lewangamage, K. T. Tse, T. P. Miyanawala, C. Ramanayaka   +6 more
semanticscholar   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Vulnerability of public buildings subjected to earthquake by finite element modelling [PDF]

, 2006
Tremors in Peninsular Malaysia and East Malaysia due to Sumatra and Philippine earthquakes have been reported several times. Engineers are concerned of the seismic vulnerability of public buildings due to lack of earthquake consideration in Malaysia’s ...
Adnan, Azlan, Darus, Zamri, Selvanayagam, P. N., Suradi, Suhana   +3 more
core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Laboratory study of tornado-like loading on a low-rise building model

Journal of Wind Engineering and Industrial Aerodynamics, 2023
Qiang Chen, Zhu Tang, Xinyang Wu, D. Zuo, D. James   +4 more
semanticscholar   +1 more source