Results 91 to 100 of about 1,578,666 (279)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Problems and prospects of cottage construction in Russia
MATEC Web of Conferences, 2016 Sustainable development of building complex in suburban territories and reorientation of building construction to low-rise construction is the actual direction of the construction industry.
Kasyanov Vitaly, Landysheva Olga
doaj +1 more source
Spinor-vector duality and light Z' in heterotic string vacua [PDF]
, 2015 We discuss the construction of heterotic--string models that allow for the existence of an extra $Z^\prime$ at low scales. One of the main difficulties encountered is that the desired symmetries tend to be anomalous in the prevailing three generation ...
Faraggi, Alon E., Rizos, John
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Criteria for selecting the vibratory pile drivers (rus) [PDF]
Инженерно-строительный журнал, 2011 Nowadays in Russia there has been intensive transition from low-rise construction to the high-rise construction. High-rise construction requires reliable foundations.
Kolosova N.B., Bulatov G.Ya
doaj
A Class of $P,T$-Invariant Topological Phases of Interacting Electrons
, 2003 We describe a class of parity- and time-reversal-invariant topological states of matter which can arise in correlated electron systems in 2+1-dimensions.
Aizenman +85 more
core +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Immigration and Wages: Evidence from Construction [PDF]
To identify relative wage impacts of immigration, we make use of certification and licensing requirements in the Norwegian construction sector that give rise to exogenous variation in immigrant employment shares across trades.
Bernt Bratsberg, Oddbjørn Raaum
core +3 more sources
Analysis of thermal parameters of the enclosing structure the object of low-rise housing construction [PDF]
E3S Web of ConferencesThe paper considers the enclosing structures of an individual housing construction object made of wood-mineral composite, brick and polystyrene concrete. The purpose of the study is to identify the thermal parameters of the wall. According to the results
Soboleva Anastasia +6 more
doaj +1 more source
Short-term Effects of Nutrients on a Barrier Island Grassland Community [PDF]
, 2017 Increased nutrient availability globally has the potential to affect community functional composition of plants in nutrient limited environments, such as coastal grassland systems.
Moulton, Ashley
core +1 more source