Results 151 to 160 of about 32,700 (291)

Nanostructured drug delivery systems for posterior segment eye diseases: Strategies to defy ocular barriers

open access: yesBMEMat, EarlyView.
Efficient drug delivery to the posterior segment of the eye has long been a challenging issue due to the complex ocular barriers. The review focuses on the promise held by nanoplatforms for barrier penetration and the key mechanisms involved, also highlighting their advantages in achieving efficient drug delivery and superior treatment of PSEDs ...
Yifan Shen   +7 more
wiley   +1 more source

N‐1 semi‐continuous transient perfusion in shake flask for ultra‐high density seeding of CHO cell cultures in benchtop bioreactors

open access: yesBiotechnology Progress, EarlyView.
Abstract One strategy to enhance the production of biological therapeutics is using transient perfusion in the preculture (N‐1 stage) to seed the production culture (N stage) at ultra‐high cell densities (>10 x 106 viable cells/mL). This very high seeding density improves cell culture performance by shortening the timeline and/or achieving higher final
Lucas Lemire   +5 more
wiley   +1 more source

Exposure Experiments to Test the Kinetic Stability of 5‐Hydroxymethylfurfural Oxidase (HMFO) in Different Reactor Environments

open access: yesChemCatChem, EarlyView.
Scaling beyond the laboratory exposes enzymes to new stresses. Exposure experiments reveal that dynamic gas‐liquid interfaces introduced by sparging or air entrainment during agitation are the main drivers of HMFO deactivation. Replacing bubbles with a membrane‐based bubble‐free aeration system dramatically enhances stability. These experiments provide
Amalie Vang Høst   +4 more
wiley   +1 more source

Fines deposition during hydrotreating: Effects of catalyst size and bed arrangement

open access: yesThe Canadian Journal of Chemical Engineering, EarlyView.
Abstract Fines deposition presents a significant problem during the hydrotreating of bitumen‐derived gas oils. The accumulation of fines leads to reactor clogging and consequently, pressure drop buildup. At critical levels, the hydrotreating reactor must be prematurely shutdown, resulting in substantial economic losses for refineries.
Simon Kwao   +3 more
wiley   +1 more source

A critical study of sustainable biocomposites developed from rheologically distinct poly(butylene adipate‐co‐terephthalate) (PBAT) reinforced with biocarbon from coconut (Cocos nucifera) for rigid applications

open access: yesThe Canadian Journal of Chemical Engineering, EarlyView.
This work highlights the development of a sustainable composite with improved dimensional and thermal stability as well as mechanical performance, for rigid application. To promote sustainability and a circular economy, we have reduced PBAT percentage content by half and incorporated waste coconut shell up to 50 wt.%.
Blessing E. Itabana   +3 more
wiley   +1 more source

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