Results 81 to 90 of about 3,420,502 (281)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Properties of Quantum Graphity at Low Temperature

, 2011
We present a mapping of dynamical graphs and, in particular, the graphs used in the Quantum Graphity models for emergent geometry, into an Ising hamiltonian on the line graph of a complete graph with a fixed number of vertices.
Caravelli, Francesco, Markopoulou, Fotini   +1 more
core   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Publisher Correction: Nonlinear two-level dynamics of quantum time crystals

Nature Communications, 2022
S. Autti, P. J. Heikkinen, J. Nissinen, J. T. Mäkinen, G. E. Volovik, V. V. Zavyalov, V. B. Eltsov   +6 more
doaj   +1 more source

Noise of a superconducting magnetic flux sensor based on a proximity Josephson junction

Scientific Reports, 2017
We demonstrate simultaneous measurements of DC transport properties and flux noise of a hybrid superconducting magnetometer based on the proximity effect (superconducting quantum interference proximity transistor, SQUIPT).
R. N. Jabdaraghi, D. S. Golubev, J. P. Pekola, J. T. Peltonen   +3 more
doaj   +1 more source

Low-temperature quantum fluctuations in overdamped ratchets

, 2010
At low temperatures and strong friction the time evolution of the density distribution in position follows a quantum Smoluchowski equation. Recently, also higher-order contributions of quantum fluctuations to drift and diffusion coefficients have been ...
H. Risken, J. Ankerhold, J. Dajka, Joachim Ankerhold, Stefan A. Maier   +4 more
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Compactive Viscosity of Snow and Its Climatic Implications at Mizuho Station, Antarctica (Special Issue of the Proceedings of the First Symposium on Antarctic Meteorology and Glaciology)

Antarctic Record, 1979
The compactive viscosity coefficient of snow was obtained from a density profile at Mizuho Station, Antarctica The value of the compactive viscosity coefficient was by two orders of magnitude larger than that of ordinary seasonal snow.
Norikazu MAENO, Hideki MAEDA
doaj   +1 more source

Slugs at Low Temperatures [PDF]

Nature, 1961
DAMAGE by slugs in gardens and farms is usually worst in late autumn and early spring. There are three reasons for this. First, some species are most numerous in winter1. Secondly, alternative foods are scarce, and crop plants such as germinating wheat or the young shoots from delphiniums are sometimes almost the only food available. Thirdly, slugs are
openaire   +1 more source