Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Low-velocity Impact Response of a Nanocomposite Beam Using an Analytical Model
Low-velocity impact of a nanocomposite beam made of glass/epoxy reinforced with multi-wall carbon nanotubes and clay nanoparticles is investigated in this study.
Mahdi Heydari Meybodi +3 more
doaj +1 more source
Assessment of Numerical Simulation Models for Impact Damage of Composite Materials
Fiber reinforced resin matrix composites(FRP) have been widely used in aerospace and other advanced structures. The study of low-speed impact damage of FRP is of important engineering application value.
Zhang Jiarui, Wu Fuqiang, Yao Weixing
doaj +1 more source
Consequences of large impacts on Enceladus' core shape [PDF]
International audienceThe intense activity on Enceladus suggests a differentiated interior consisting of a rocky core, an internal ocean and an icy mantle.
Choblet, G +3 more
core +2 more sources
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Impact Dynamics of Oxidized Liquid Metal Drops
With exposure to air, many liquid metals spontaneously generate an oxide layer on their surface. In oscillatory rheological tests, this skin is found to introduce a yield stress that typically dominates the elastic response but can be tuned by exposing ...
Brown, Eric +2 more
core +1 more source
Time after time – circadian clocks through the lens of oscillator theory
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Study of the behavior of damaged low-velocity impact carbon/epoxy/AL2024-T3 hybrid laminates
Aluminium and layered composite structures currently play a crucial role in the aviation sector. These structures may be susceptible to inadvertent impacts from several sources.
Fatima Zohra Daouache +7 more
doaj +1 more source
Damage in CFRPs due to low velocity impact at low temperature [PDF]
10 pages, 21 figures.This work examines the response of carbon fibre-reinforced epoxy matrix (CFRP) laminates at low impact velocity and in low temperature conditions.
Barbero Pozuelo, Enrique +3 more
core +3 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source

