Results 51 to 60 of about 456,505 (306)
Advances in Civil Engineering, 2017 In the state of Colorado, the Colorado Department of Transportation (CDOT) utilizes their pavement management system (PMS) to manage approximately 9,100 miles of interstate, highways, and low-volume roads.
Promothes Saha +2 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Estimating the resilient modulus of subgrade materials using visual inspection
Transportes, 2022 The definition of the Resilient Modulus (MR) of subgrade soils is essential for the reliable implementation of mechanistic-empirical pavement design. The MR of the soil is measured through repeated triaxial load tests which require expensive equipment ...
Wana Maria de Souza +2 more
doaj +1 more source
Modeling spatial variability in the life-cycle costs of low-volume forest roads [PDF]
, 2018 Cost estimation is probably the most decisive factor in the process of computer-aided, preliminary planning for low-volume road networks. However, the cost of construction is normally assumed to be route-independent for a specific project area, resulting
Burlet, Edouard +2 more
core
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Effect of the standard levels of forest road segments on soil loss
Journal of Forest Science, 2021 Roads with the low standard level are often more susceptible to soil loss and production of sediment during rainfall events. The main aims of this research were to investigate the relationships between the standard level of the road and soil loss and ...
Ghaffar Yolmeh +3 more
doaj +1 more source
Cities, traffic, and CO2: A multidecadal assessment of trends, drivers, and scaling relationships [PDF]
, 2015 Emissions of CO2 from road vehicles were 1.57 billion metric tons in 2012, accounting for 28% of US fossil fuel CO2 emissions, but the spatial distributions of these emissions are highly uncertain.
Gately, Conor K. +2 more
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
2 + 1 Highways: Overview and Future Directions [PDF]
, 2018 Most of the rural transportation system is composed of two-lane highways, and many of them serve as the primary means for rural access to urban areas and freeways.
Martin Gasulla, Marilo +2 more
core +3 more sources
Autophagosome marker, LC3, is released extracellularly via several distinct pathways
FEBS Open Bio, EarlyView.This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito +3 more
wiley +1 more source