Latin American clubs: uncovering patterns of convergence [PDF]
This paper explores the dynamics of convergence in Latin American countries and asks whether there are tendencies for converging to different clubs. The analysis shows clear differences between two groups: a large group of low-to-middle income countries ...
Blyde, Juan
core +1 more source
ZNRD2 Mediated Nucleoprotein Aggregation Impairs Respiratory Syncytial Virus Replication
Advanced Science, EarlyView.During RSV infection, nucleoprotein (N) forms RNA‐bound oligomers. The host protein ZNRD2 binds to these oligomers, promoting their transition into insoluble aggregates. These aggregates simultaneously sequester functional N to restrict viral production and disrupt chaperonin assembly quality control by interfering with ZNRD2's role as an adaptor ...
Haiwu Zhou +8 more
wiley +1 more source
Acute Kidney Injury: Risk Factors and Management Challenges in Low- and Middle-Income Countries
European Medical Journal Nephrology, 2020 Acute kidney injury (AKI) is a major global health problem, occurring in >13 million people and responsible for >2.3 million deaths every year, 85% of which are in developing countries. Although the International Society of Nephrology (ISN) set a goal of
Daniela Ponce +3 more
doaj
Cervical cancer in low and middle income countries: Addressing barriers to radiotherapy delivery
Gynecologic Oncology Reports, 2017 The global cervical cancer burden falls disproportionately upon women in low and middle-income countries. Insufficient infrastructure, lack of access to preventive HPV vaccines, screening, and treatment, as well as limited trained personnel and training ...
Anna W. LaVigne +4 more
doaj +1 more source
The U.S. recession could hurt the South, particularly in oil and apparel exports, and Latin America and the Caribbean. But South-South trade is partly picking up the slack.
Canuto, Otaviano +2 more
core
Immune Predictors of Radiotherapy Outcomes in Cervical Cancer
Advanced Science, EarlyView.This study reveals dynamic immune remodeling in cervical cancer following radiotherapy. Single‐cell analysis identifies the C3/C3AR1 axis as a central mediator of epithelial–myeloid crosstalk, whose inhibition reduces treatment efficacy in mice. Guided by these insights, the eight‐feature machine‐learning model: Cervical Cancer Radiotherapy Immune ...
Linghao Wang +8 more
wiley +1 more source
Grow rich and clean up later? International assistance and the provision of environmental quality in low- and middle-income countries [PDF]
This paper deals with the question whether low- and middle-income countries that are politically better integrated into the international system are able to provide higher levels of environmental quality than could be expected only according to their ...
Ruoff, Gabi
core
Discovery of a Novel DNMT1 Inhibitor with Improved Efficacy in Treating β‐Thalassemia
Advanced Science, EarlyView.Context of Research: β‐thalassemia affects millions worldwide. DNMT inhibitors are effective HbF‐inducers that benefit patients with β‐thalassemia. Existing DNMT inhibitors are not approved for β‐thalassemia treatment due to dose‐limiting toxicity.What We Find: DMT207 traps DNMT1 into helix‐kinked inactive conformation and enhances its interaction with
Yijie Shen +19 more
wiley +1 more source
Assessing the potential of wearable health monitors for health system strengthening in low- and middle-income countries: a prospective study of technology adoption in Cambodia [PDF]
, 2022 Marco Liverani +5 more
openalex +1 more source
Advanced Science, EarlyView.Cancer‐associated fibroblasts (CAFs) in prostate tumors exhibit distinct morphomechanical traits vs normal fibroblasts, including greater stiffness and volume, more elongated stress fibres, and larger and more elongated nuclei. These features, quantified through imaging and real‐time deformability cytometry, correlate with patient outcomes and can be ...
Antje Garside +11 more
wiley +1 more source