Results 181 to 190 of about 1,256,344 (293)

Advancing chronic low back pain management: Insights from amitriptyline and duloxetine comparison. [PDF]

World J Methodol
Rath S.
europepmc   +1 more source

A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain

Advanced Science, EarlyView.
Zhang et al. uncover a novel central mechanism for persistent muscle pain, in which TRPA1 sensitization in MeV proprioceptive neurons enhances somatic secretion. This, in turn, disinhibits descending pain control from neighboring noradrenergic locus coeruleus neurons via local GABAergic circuits, thereby promoting inflammatory muscle pain.
Xiaoyu Zhang, Jiale Yang, Xi Wu, Jie Li, Fujian Lu, Yiman Li, Xingyu Du, Rong Huang, Jamila Asgar, Jing Wang, Ke Ren, Feipeng Zhu, Changhe Wang, Yehua Gan, Feng Wei, Zhuan Zhou   +15 more
wiley   +1 more source

The Impact of Brain Morphometry on Low Back Pain Risk: A Mendelian Randomization Study. [PDF]

J Pain Res
Liu Z, Li Y, Dai Y, Jiang B, Ma H, Tu Z, Wang B.   +6 more
europepmc   +1 more source

Deciphering and Targeting the Schwannoma‐Neuron‐Macrophage Crosstalk for the Treatment of Schwannomatosis and Associated Pain

Advanced Science, EarlyView.
We established patient‐derived SWN cell lines and orthotopic PDX models that recapitulate patient pain phenotypes, alongside a novel intravital DRG imaging platform to track macrophage infiltration and neuronal pain responses. Using these models, we define HMGB1–CCL2–IL‐6 signaling crosstalk driving pain and identify EGF signaling as a key regulator of
Zhenzhen Yin, Limeng Wu, Yanling Zhang, Yao Sun, Grace Y. Lee, Simeng Lu, Xing Gao, John W. Chen, Sonu Subudhi, William Ho, Chao Zhu, Jun Ren, Gino B. Ferraro, Alona Muzikansky, Anat Stemmer‐Rachamimov, Jianren Mao, Scott R. Plotkin, Lei Xu   +17 more
wiley   +1 more source

Exploring physicians' perspectives on influencing factors of chronic non-specific low back pain: a qualitative study. [PDF]

Scand J Prim Health Care
Vanderstraeten R, Fourré A, Demeure I, Bastiaens H, Demoulin C, Michielsen J, Anthierens S, Roussel N.   +7 more
europepmc   +1 more source

Ultrasound Modulation of Visual Circuits in Mice Independent of Auditory Confound

Advanced Science, EarlyView.
In this study, Qiu et al. found that low‐intensity ultrasound can directly activate sparse ultrasound‐sensitive neurons (UNs) in the primary visual cortex (V1) of deafened mice. The proportion of these sparse UNs is pressure‐dependent. Furthermore, ultrasound modulates visual circuitry with distinct excitatory and inhibitory effects.
Jiaru He, Jiejun Zhu, Xinxin Wang, Zihao Chen, Jin Yang, Zhen Yuan, Hongzhi Xu, Lei Sun, Zhihai Qiu   +8 more
wiley   +1 more source

An Unsupervised Learning Approach for Multimodal Low Back Pain Stratification. [PDF]

Spine (Phila Pa 1976)
Kowlagi N, Heikkala E, Saarakkala S, Karppinen J, Tiulpin A.   +4 more
europepmc   +1 more source

A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia

Advanced Science, EarlyView.
A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun, Jia‐Jia Wang, Xiang‐Yu Li, Xin‐Yi Lin, Juan Li, Qiu‐Tong Yu, Zi‐Han Wang, Xue‐Ping Gao, Lei Jin, Wei‐Ke Li, Tian‐Lin Cheng, Juan Deng   +11 more
wiley   +1 more source

Correction: A study of the correlation between urinary perchlorate, nitrate, thiocyanate, and serum liver function indices

Scientific Reports
Wancheng Zhang, Jianglong Ling, Lixiu Lan, Qiuhong Guo, Ye Ruan, Dingchang Wu   +5 more
doaj   +1 more source

In the Light of Healthcare Professionals: Beliefs About Chronic Low Back Pain. [PDF]

Medicina (Kaunas)
Péter B, Georgescu A, Popovici IM, Popescu L, Szabó-Csifó T, Radu LE, Fagaras PS.   +6 more
europepmc   +1 more source