Results 251 to 260 of about 713,182 (320)

Dendrimer Conjugates with PD‐L1‐Binding Peptides Enhance In Vivo Antitumor Immune Response

open access: yesAdvanced Healthcare Materials, EarlyView.
In this paper, a novel nanoparticle scaffold composed of dendrimers conjugated with peptide‐based immune checkpoint inhibitors, enhancing drug delivery efficacy is introduced. By conjugating PD‐L1‐binding peptides to dendrimers, multivalent binding effects are harnessed, resulting in enhanced binding affinity, prolonged half‐life, and improved ...
DaWon Kim   +11 more
wiley   +1 more source

Biofunctionalization of ADA‐GEL Hydrogels Based on the Degree of Cross‐Linking and Polymer Concentration Improves Angiogenesis

open access: yesAdvanced Healthcare Materials, EarlyView.
The biocompatibility of alginate dialdehyde (ADA) and gelatin (GEL) hydrogels cross‐linked with human transglutaminase (hTG) is demonstrated in vivo with a high degree of stability and angiogenic potential. The additional enzymatic cross‐linker hTG and the increased concentration improve stability and angiogenic potential. The X‐ray microscopy (XRM) is
Stefanie Heltmann‐Meyer   +12 more
wiley   +1 more source

Self‐Healing Hydrogel Dressing with Solubilized Flavonoids for Whole Layer Regeneration of Diabetic Wound

open access: yesAdvanced Healthcare Materials, EarlyView.
High glucose‐ and acid‐responsive hydrogel with dynamic covalent bond solubilized with flavonoids (Gel‐Flavonoids) is designed for diabetic wound healing. The Gel‐Flavonoids adapt to irregular wound shapes and release antioxidants in high‐glucose environments, effectively reducing reactive oxygen species.
Qiang Zeng   +9 more
wiley   +1 more source

Tumor‐Targeted Exosome‐Based Heavy Atom‐Free Nanosensitizers With Long‐Lived Excited States for Safe and Effective Sono‐Photodynamic Therapy of Solid Tumors

open access: yesAdvanced Healthcare Materials, EarlyView.
Engineered exosome‐based heavy atom‐free nanosensitizers are developed for safe and targeted sono‐photodynamic therapy of solid tumors. The IR820‐TPE‐loaded, biotin‐conjugated exosomes (IR820‐TPE@B‐Exo) demonstrate significant promise for NIR fluorescence imaging‐guided sono‐photodynamic cancer therapy.
Van‐Nghia Nguyen   +16 more
wiley   +1 more source

Designing for Degradation: Transient Devices Enabled by (Nano)Cellulose

open access: yesAdvanced Materials, EarlyView.
Recent progress in transient devices enabled by (nano)cellulosic materials is reviewed. Transiency mechanisms, advantages of nanocelluloses, and a suite of applications are discussed. A circular thinking approach coupled with life cycle assessment is applied to critically revisit the potential, advantages, and challenges of nanocellulose‐enabled ...
Lucas J. Andrew   +2 more
wiley   +1 more source

Digitonin‐Loaded Nanoscale Metal–Organic Framework for Mitochondria‐Targeted Radiotherapy‐Radiodynamic Therapy and Disulfidptosis

open access: yesAdvanced Materials, EarlyView.
A mitochondria‐targeted cationic nanoscale metal organic framework shows strong radiotherapy‐radiodynamic therapy effects and selectively releases digitonin in acidic tumor microenvironments to induce disulfidptosis of cancer cells and downregulate immune checkpoints in cancer and T cells, thereby eliciting strong antitumor immunity to effectively ...
Wenyao Zhen   +7 more
wiley   +1 more source

Enhancing Ultrasound Power Transfer: Efficiency, Acoustics, and Future Directions

open access: yesAdvanced Materials, EarlyView.
Implantable devices significantly enhance healthcare but are limited by battery life. Ultrasound power transfer technology offers a promising solution for sustainable operation. This review addresses gaps in current research, particularly in sound field analysis and energy efficiency optimization.
Yi Zheng   +6 more
wiley   +1 more source

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