Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
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Survey the Effect of Low Dose Aspirin on Serum Level of Uric Acid in Patients with Ischemic Heart Disease [PDF]
Background & Objectives: Low dose aspirin has been widely used in the prevention and treatment of cardiovascular disease. The bimodel action of aspirin on serum uric acid showed that aspirin at a high dosage promoted uricusuria; while intermediate doses ...
حسینیان, عدالت +6 more
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Retrospective analysis of cases with low dose methotrexate-induced neutropenia [PDF]
Objective: Low dosemethotrexate (MTX) is among the most commonly used drugs in rheumatology and rarely associated with neutropenia. It is generally observed as a result of improper use or in patients with risk factors for toxicity.
Elif Dinçses Nas, Sevilay Batıbay
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Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
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MR urography after low-dose diuretic injection in the evaluation of urinary tract obstruction
, 2003 Purpose: To evaluate the diagnostic capability of the MR-urography with low-dose diuretic injection in the evaluation of urinary tract obstruction. Methods and Materials: 55 patients suffering symptoms by obstructive uropathy underwent MR examination ...
M. Di Pietro +5 more
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Clusterin: an IR-inducible protein determining life and death
, 2006 The roles of ionizing radiation (IR)-inducible genes/proteins are now being elucidated and the research team will focus on the functions of the clusterin (CLU) proteins after low dose IR exposures.
Boothman, David A.
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Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Progress in low dose health risk research: Novel effects and new concepts in low dose radiobiology
, 2018 People are more often exposed to low as opposed to high doses of ionising radiation (IR). Knowledge on the health risks associated with exposures to ionising radiation above 100 mGy is quite well established, while lower dose risks are inferred from ...
Ottolenghi, Andrea +11 more
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Comparison of low-dose CT with CT/CT fluoroscopy guidance in percutaneous sacral and supra-acetabular cementoplasty [PDF]
, 2019 PURPOSEPercutaneous cementoplasty is a minimally invasive treatment modality for painful osteoporotic and pathologic sacral and supra-acetabular iliac fractures.
Veer Shah, Jack Jennings, Travis Hillen
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