Results 81 to 90 of about 320,872 (316)

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Validating the Effectiveness of Fine-Tuning for Semantic Classification of Japanese Katakana Words: An Analysis of Frequency and Polysemy Effects on Accuracy

Big Data and Cognitive Computing
In semantic classification of katakana words using large language models and pre-trained language models, semantic divergences from original English meanings, such as those found in Wasei-Eigo which is Japanese-made English, and the inherent sense ...
Kazuki Kodaki, Minoru Sasaki
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Effects of Multimedia Instruction on L2 Acquisition of High-Level, Low-Frequency English Vocabulary Words [PDF]

, 2017
The present study examined the effects of multimedia enhancement in video form in addition to textual information on L2 vocabulary instruction for high-level, low-frequency English words among Korean learners of English.
Euna Cho
openalex   +3 more sources

Regional amplitude of the low-frequency fluctuations at rest predicts word-reading skill

Neuroscience, 2015
Individuals' reading skills are critical for their educational development, but variation in reading skills is known to be large. The present study used functional magnetic resonance imaging (fMRI) to examine the role of spontaneous brain activity at rest in individual differences in reading skills in a large sample of participants (N=263 ...
Xu, M., Beuckelaer, A. de, Wang, X, Liu, L., Song, Y., Liu, J.   +5 more
openaire   +3 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Learning the meaning of new words: Behavioural and neuroimaging evidence [PDF]

, 2011
This thesis aimed to shed light on the process of word learning and the consequences of storing, retrieving, and using new lexical representations. A number of behavioural experiments and one final fMRI study were conducted.
Ferreira, Roberto A., Ferreira, Roberto A   +1 more
core  

The effect of high- and low-frequency previews and sentential fit on word skipping during reading [PDF]

, 2014
In a previous gaze-contingent boundary experiment, Angele and Rayner (2013) found that readers are likely to skip a word that appears to be the definite article the even when syntactic constraints do not allow for articles to occur in that position.
Angele, Bernhard, Laishley, Abby E., Liversedge, Simon P., Liversedge, S.P., Liversedge, Simon Paul, Laishley, A.E., Rayner, K., Rayner, Keith   +7 more
core   +1 more source

Top-Down and/or Bottom-Up Processing in Iranian EFL Learners'''' Listening Comprehension at Pre-Intermediate Level [PDF]

Matn/Pizhūhī-i Adabī, 2007
This research is aimed at finding out whether Iranian EFL learners of English at the pre-intermediate level would prefer bottom-up or top-down processing in their listening comprehension. There were 90 students, 72 girls and 18 boys.
mohammad khatib, reza taherkhani
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source