Results 241 to 250 of about 7,413,046 (314)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

The role of large immune complexes in anti-drug antibody development: a case study of anti-SARS-CoV-2 antibody therapeutics and co-administered mRNA vaccine. [PDF]

Front Immunol
Irvin SC, Wang Z, Ganguly S, Choudhary D, Kanagaraj M, Liu N, Isa F, He ZW, Yan H, Casullo VM, Turner KC, Davis JD, Rosconi MP, Torri A, Partridge MA.   +14 more
europepmc   +1 more source

ICT for Low Environmental Impact (Sustainable) Development

Material Cycles and Waste Management Research, 2013
openaire   +2 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Rising Air-Conditioning Use Intensifies Global Warming. [PDF]

Nat Commun
Zhang H, Shan Y, Li R, Xue R, Ma J, Kikstra J, Shi Z, Wang Z, Zhang B, Wang B, Fang S, Yang F, Hubacek K.   +12 more
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Impact of digital trade on tourism carbon emission reduction in China under industrial agglomeration and low carbon pilot policies. [PDF]

Sci Rep
Yu Z, Shi X, Liu W, Wu X.
europepmc   +1 more source

Low-carbon pilot policy and urban carbon metabolism efficiency: evidence from China. [PDF]

Carbon Balance Manag
Wang H, Shi X.
europepmc   +1 more source

Differentiating the thermal effects of land use change and functional intensity dynamics in Beijing. [PDF]

Sci Rep
Wei H, Gong A, Wan J, Zhang J, Fu Z, Jiang M.   +5 more
europepmc   +1 more source

Key barriers and solutions for decarbonizing Egypt's construction sector. [PDF]

Sci Rep
Harb S, Abotaleb IS, Ezeldin AS.
europepmc   +1 more source