Results 111 to 120 of about 3,156,291 (263)

OGLE-2017-BLG-0448Lb: A Low Mass–Ratio Wide-orbit Microlensing Planet?

open access: yesThe Astronomical Journal
The gravitational microlensing technique is most sensitive to planets in a Jupiter-like orbit and has detected more than 200 planets. However, only a few wide-orbit ( s > 2) microlensing planets have been discovered, where s is the planet-to-host ...
Ruocheng Zhai   +44 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

Flavor imprints on novel low mass dark matter

open access: yesJournal of High Energy Physics
We present a Majorana scotogenic-like loop framework in which neutrino mass generation and dark matter stability are intrinsically connected to the breaking of the discrete flavor symmetry A 4.
Ranjeet Kumar   +3 more
doaj   +1 more source

Author Correction: Imaging low-mass planets within the habitable zone of α Centauri. [PDF]

open access: yesNat Commun, 2021
Wagner K   +41 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Tidally Delayed Spin-Down of Very Low Mass Stars

open access: yesThe Open Journal of Astrophysics
Very low-mass main-sequence stars reveal some curious trends in observed rotation period distributions that require abating the spin-down that standard rotational evolution models would otherwise imply.
Ketevan Kotorashvili, Eric G. Blackman
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

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