Results 141 to 150 of about 6,573,875 (320)
Demonstration of Intercoronary Anastomoses in Human Hearts with a Low Viscosity Perfusion Mass [PDF]
, 1966 Stanley L. Robbins +2 more
openalex +1 more source
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence
Molecular Oncology, EarlyView.The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova +18 more
wiley +1 more source
Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
Formaldehyde emission from low mass protostars
, 2003 We present a survey of the formaldehyde emission in nine class 0 protostars obtained with the IRAM 30m and the JCMT millimeter telescopes. Using a detailed radiative transfer code of the envelopes surrounding the protostars, we show that all but one of ...
Maret, Sebastien
core +1 more source
Journal of Materials Research and TechnologyA new model is presented for the interpretation of the nearly linear Stage IV large strain hardening behavior observed in polycrystalline metals.
Laszlo S. Toth, Anthony D. Rollett
doaj
The Low-mass Stellar Initial Mass Function in Nearby Ultrafaint Dwarf Galaxies
The Astrophysical JournalThe stellar initial mass function (IMF) describes the distribution of stellar masses that form in a given star formation event. The long main-sequence lifetimes of low-mass stars mean that the IMF in this regime (below ∼ 1 M _⊙ ) can be investigated ...
Carrie Filion +5 more
doaj +1 more source
Landscape of BRAF transcript variants in human cancer
Molecular Oncology, EarlyView.We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda +5 more
wiley +1 more source
Erratum: Direct Measurement of Mass Pickup in a Low-Energy Theta Pinch [PDF]
, 1968 Robert W. Harris
openalex +1 more source