Results 161 to 170 of about 17,065,072 (359)

Strength through diversity: how cancers thrive when clones cooperate

open access: yesMolecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken   +3 more
wiley   +1 more source

Search for low-mass dilepton resonances in Higgs boson decays to four-lepton final states in proton-proton collisions at s = 13 TeV. [PDF]

open access: yesEur Phys J C Part Fields, 2022
Tumasyan A   +2348 more
europepmc   +1 more source

Low-Mass Red Giants

open access: yesThe Astrophysical Journal, 1968
Red giants limiting helium core mass dependence on total stellar mass and initial composition from stellar evolutionary ...
openaire   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

A design-of-experiments strategy for engineering 3D topographical features in osteosarcoma modelling

open access: yesMaterials Today Bio
Osteosarcoma is a highly aggressive bone cancer with poor patient outcomes, partly due to the limited predictive power of current preclinical models. Conventional two-dimensional (2D) cultures fail to recapitulate physiologically relevant cell-matrix ...
Kozim Midkhatov   +3 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

The Low-mass Stellar Initial Mass Function in Nearby Ultrafaint Dwarf Galaxies

open access: yesThe Astrophysical Journal
The stellar initial mass function (IMF) describes the distribution of stellar masses that form in a given star formation event. The long main-sequence lifetimes of low-mass stars mean that the IMF in this regime (below ∼ 1 M _⊙ ) can be investigated ...
Carrie Filion   +5 more
doaj   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

open access: yesMolecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj   +4 more
wiley   +1 more source

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