Results 91 to 100 of about 4,847,627 (305)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

A Wideband Quad-Polarization Reconfigurable Metasurface Antenna

IEEE Access, 2018
A low-profile wideband metasurface antenna with quad-polarization reconfiguration ability is presented in this paper. The proposed metasurface antenna is composed of a square patch, a metasurface formed by a lattice of 4 × 4 periodic metal plates,
Jun Hu, Guo Qing Luo, Zhang-Cheng Hao
doaj   +1 more source

The 2D dynamics of radiative zones of low-mass stars

, 2017
In the context of secular evolution, we describe the dynamics of the radiative core of low-mass stars to understand the internal transport of angular momentum in such stars which results in a solid rotation in the Sun from 0.7R_sun to 0.2R_sun and a weak
Hypolite, D., Mathis, S., Rieutord, M.
core   +3 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

A Novel Methodology for Gain Enhancement of the Fabry-Pérot Antenna

IEEE Access, 2019
A significant problem that is encountered with the traditional Fabry-Pérot cavity (FPC) antenna is the nonuniform phase distribution inside the cavity, which adversely affects the radiation characteristics of the antenna.
Peng Xie, Guangming Wang, Haipeng Li, Xiangjun Gao   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The Belgian paradox: high EU profile, low EU interest [PDF]

, 2010
A
Vos, Hendrik
core   +1 more source

The Redshift Evolution of the Mean Temperature, Pressure, and Entropy Profiles in 80 SPT-Selected Galaxy Clusters

, 2014
(Abridged) We present the results of an X-ray analysis of 80 galaxy clusters selected in the 2500 deg^2 South Pole Telescope survey and observed with the Chandra X-ray Observatory.
Aird, K. A., Allen, S. W., Bautz, M., Bayliss, M., Benson, B. A., Bleem, L. E., Bocquet, S., Brodwin, M., Carlstrom, J. E., Chang, C. L., Cho, H. M., Clocchiatti, A., Crawford, T. M., Crites, A. T., de Haan, T., Dobbs, M. A., Foley, R. J., Forman, W. R., George, E. M., Gladders, M. D., Gonzalez, A. H., Halverson, N. W., Hlavacek-Larrondo, J., Holder, G. P., Holzapfel, W. L., Hrubes, J. D., Jones, C., Keisler, R., Knox, L., Lee, A. T., Leitch, E. M., Liu, J., Lueker, M., Luong-Van, D., Mantz, A., Marrone, D. P., McDonald, M., McMahon, J. J., Meyer, S. S., Miller, E. D., Mocanu, L., Mohr, J. J., Murray, S. S., Padin, S., Pryke, C., Reichardt, C. L., Rest, A., Ruhl, J. E., Saliwanchik, B. R., Saro, A., Sayre, J. T., Schaffer, K. K., Shirokoff, E., Spieler, H. G., Stalder, B., Stanford, S. A., Staniszewski, Z., Stark, A. A., Story, K. T., Stubbs, C. W., Vanderlinde, K., Vieira, J. D., Vikhlinin, A., Williamson, R., Zahn, O., Zenteno, A.   +65 more
core   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source