Results 111 to 120 of about 4,847,627 (305)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The spectroscopic evolution of the symbiotic-like recurrent nova V407 Cygni during its 2010 outburst. I. The shock and its evolution

, 2010
On 2010 Mar 10, V407 Cyg was discovered in outburst, eventually reaching V< 8 and detected by Fermi. Using medium and high resolution ground-based optical spectra, visual and Swift UV photometry, and Swift X-ray spectrophotometry, we describe the ...
A. P., Augusteijn, Beardmore, G. M., J. P., K. L., Koubsky, Liimets, M., Osborne, P., Page, Shore S.N., T., T., V., Votruba, Wahlgren, Šlechta   +18 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Amplified wind turbine apparatus [PDF]

, 1982
An invention related to the utilization of wind energy and increasing the effects thereof for power generation is described. Amplified wind turbine apparatus is disclosed wherein ambient inlet air is prerotated in a first air rotation chamber having a ...
Hein, L. A., Myers, W. N.
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Emission-line profile modelling of structured T Tauri magnetospheres

, 2005
We present hydrogen emission line profile models of magnetospheric accretion onto Classical T Tauri stars. The models are computed under the Sobolev approximation using the three-dimensional Monte Carlo radiative-transfer code TORUS.
Alencar, Alencar, Alencar, Armitage, Basri, Bertout, Bouvier, Bouvier, Choi, Collier Cameron, Decampli, Edwards, Harries, Harries, Hartmann, Hartmann, Hartmann, Hartmann, Johns, Johns, Johns-Krull, Klein, Koenigl, Kurosawa, Kurosawa, Kurucz, Lawson, Martin, Miller, Muzerolle, Muzerolle, Muzerolle, Neil H. Symington, Oliveira, Paatz, Petrov, Romanova, Ryuichi Kurosawa, Shu, Smith, Smith, Stassun, Steinacker, Stempels, Symington, Tim J. Harries, Valenti   +46 more
core   +2 more sources

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Compact High-Frequency-Ratio Tri-Band Antenna for Sub-6 GHz and mmWave Co-Integration

IEEE Access
Next-generation wireless systems require compact antennas that can operate across both sub-6 GHz and millimeter-wave (mmWave) bands while maintaining high efficiency and a low profile.
Md Nur Alam, Md Shakiul Jafor, Md Khadimul Islam, Elias A. Alwan   +3 more
doaj   +1 more source