Results 41 to 50 of about 11,043,311 (307)

Transanal Inside-Out Rectal Resection for Ultra-Low Rectal Cancer

Journal of Investigative Surgery, 2012
Two major issues encountered in the surgical resection of low rectal cancers (tumor located
Yeh, Yung-Sung, Chen, Ming-Jenn, Tsai, Hsiang-Lin, Huang, Ming-Yii, Chen, Chao-Wen, Huang, Yu-Ho, Sheen, Maw-Chang, Wang, Jaw-Yuan   +7 more
openaire   +3 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Low anterior resection syndrome after rectal cancer surgery: mechanisms, assessment, management, and the potential role of robotic surgery

Frontiers in Oncology
Rectal cancer is one of the most commonly diagnosed malignancies in the digestive system. In recent years, with continuous advances in systemic therapies such as chemotherapy and radiotherapy, as well as the widespread implementation of the ...
Chenyu Zhang, Yuzhou Mei, Huiming Wu, Tengfei Wang, Zhenguo Han   +4 more
doaj   +1 more source

Rectal perforation after neoadjuvant chemoradiotherapy for low-lying rectal cancer [PDF]

BMJ Case Reports, 2015
A 55-year-old woman was referred to the colorectal surgery unit after receiving long course neoadjuvant chemoradiotherapy (total dose of 45 Gy over 5 weeks) for low-lying rectal adenocarcinoma, 5 cm from the anal verge, with clinical stage cT3N1M0. The patient reported of lower abdominal pain with diarrhoea and tenesmus during the last few days of the ...
openaire   +2 more sources

Gene and microRNA expression predictive of tumour response in patients treated with preoperative chemoradiotherapy for rectal cancer [PDF]

, 2013
Background Preoperative chemoradiotherapy (pCRT) followed by surgery is the standard treatment for locally advanced rectal cancer (LARC). However, the response to pCRT is not uniform, and there is no effective method to predict tumour response to pCRT ...
Maretto, I
core  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

A New Approach to Ultra‐Low Anterior Resection—Intersphincteric Dissection With Total Hiatal Ligament Excision for Very Low Rectal Cancer Located in the Posterior Wall of the Rectum: A More Satisfactory Technique for Local Recurrence Control

Cancer Medicine
Background The hiatal ligament, as the anatomical landmark for the completion of total mesorectal excision (TME) for ultra‐low rectal cancer, represents a continuation of the longitudinal muscle of the rectum.
Shoufeng Li, Ye Wang, Huajun Cai, Zhen Pan, Xing Liu, Jinfu Zhuang, Guoxian Guan   +6 more
doaj   +1 more source

Significance of carcinoembryonic antigen mRNA in peritoneal lavage determined by transcription–reverse transcription concerted method in patients with low rectal cancer

Asian Journal of Surgery, 2018
Summary: Background/Objective: Positive carcinoembryonic antigen (CEA) messenger RNA (mRNA) in peritoneal lavage is associated with poor prognosis in patients with colon cancer. However, there are no reports about rectal cancer.
Koji Murono, Soichiro Ishihara, Kazushige Kawai, Manabu Kaneko, Kazuhito Sasaki, Kensuke Otani, Koji Yasuda, Takeshi Nishikawa, Toshiaki Tanaka, Tomomichi Kiyomatsu, Keisuke Hata, Hiroaki Nozawa, Yumiko Satoh, Makiko Kurihara, Yutaka Yatomi, Toshiaki Watanabe   +15 more
doaj   +1 more source

Intersphincteric Resection for Low Rectal Cancer: A Review of Anatomy and Surgical Techniques, Oncologic and Functional Outcomes and the Role of Robotics

, 2020
Intersphincteric resection (ISR) for low rectal cancer is a relatively novel anal-sparing technique that requires a thorough knowledge of the anatomy of the deep pelvic space and advanced surgical skills.
Guglielmo Niccolò Piozzi, Hyunmi Park, Tae-Sun Choi, Seon-Hahn Kim   +3 more
core   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source