Results 71 to 80 of about 11,043,311 (307)

Lower hospital volume is associated with higher mortality after oesophageal, gastric, pancreatic and rectal cancer resection

Swiss Medical Weekly, 2017
BACKGROUND In various countries, the association of lower hospital volume and higher mortality after oesophageal, gastric, pancreatic and rectal cancer resection has been clearly demonstrated. However, scientific evidence regarding the volume-
Ulrich Güller, Rene Warschkow, Christoph Jakob Ackermann, Bruno M. Schmied, Thomas Cerny, Silvia Ess   +5 more
doaj   +1 more source

Single‐Cell RNA Editing Identifies T Cell ADAR1 as a Key Regulator of Immune Exhaustion and Anti‐PD‐1 Resistance in Colorectal Cancer

Advanced Science, EarlyView.
Single‐cell RNA editing analysis identifies ADAR1 as a regulator of dysfunctional T cell states in colorectal cancer. Elevated ADAR1 activity promotes T cell exhaustion and impairs antitumor immunity partly through TGF‐β‐SMAD signaling, contributing to anti‐PD‐1 resistance and highlighting T cell ADAR1 as a potential therapeutic target and biomarker ...
Da Kang, Song‐Zuo Xie, Yong‐Zhou Luo, Xin‐Pei Deng, Xi‐Rong Tan, Ze‐Geng Chen, Ling‐Xing Zeng, Gong Chen, Pei‐Rong Ding, Zhi‐Zhong Pan, Rong‐Xin Zhang   +10 more
wiley   +1 more source

A case of local recurrence of T1 rectal cancer 10 years after transanal excision

, 2018
2018-02We report a case of a patient with T1 rectal cancer, which recurred locally after 10 years from the primary operation. A 78-year-old woman was diagnosed with rectal cancer. Transanal excision (TAE) was performed in December 2006.
Hosoi, Takahiro, Tsutsuyama, Masayuki, Komori, Koji, Uchino, Tairin, Tanaka, Hideharu, Oshiro, Taihei, Ouchi, Akira, Shimizu, Yasuhiro, Kinoshita, Takashi, Ito, Yuichi, Shigeyoshi, Itaru, Natsume, Seiji, Hayashi, Daisuke, Kunitomo, Aina, An, Byonggu, Abe, Tetsuya, Uemura, Norihisa, Higaki, Eiji, Senda, Yoshiki, Misawa, Kazunari, Ito, Seiji, Akazawa, Tomoyuki   +21 more
core   +1 more source

Multi‐Component Functionalized Bifidobacterium Longum Hydrogel for Multi‐Target Integrated Therapy of Colitis‐Associated Anxiety and Depression

Advanced Science, EarlyView.
A pH/MMP dual‐responsive Bifidobacterium longum (BL) hydrogel (INPs@BL@Gel) functionalized with baicalin, tyrosine, and inulin is constructed. It enables gastric protection, inflammation‐targeted release, and prolonged intestinal colonization. By remodeling gut microbiota, elevating beneficial neuroactive metabolites (homovanillic acid, short‐chain ...
Shuo Zhang, Yujie Zhang, Jiansheng He, Shunlian Li, Qingyan Ma, Qiao Li, Yudan Zhang, Yiyang Wang, Shaobo Ma, Songyan Jin, Chune Li, Xueyong Xie, Hang Zhang, Junze Deng, Xueqin Song, Daocheng Wu, Xiancang Ma, Feng Zhu   +17 more
wiley   +1 more source

Photodynamic therapy combined with radiofrequency ablation and systemic therapy for KRAS-mutant advanced low rectal cancer: A case report

Photodiagnosis and Photodynamic Therapy
The overall incidence of colorectal cancer, particularly the lower part of the rectum normally known as low rectal cancer, is globally on the rise, accounting for approximately 10% of all new oncology cases.
Lingzhi Liao, Yifan Li, Jing Liu, Yali Li, Jingwei Ma, Yile Qi, Jiahui Ma, Hao Chen   +7 more
doaj   +1 more source

LOW ANTERIOR RESECTION FOR DISTAL RECTAL CANCER

Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2019
The classical approach to radical surgery of cancer of the lower rectal ampulla requires abdominoperineal resection which is technically easy to perform and is often applied in surgical units, however the procedure leads to life-long disability.
Karavai A. V., Bialiayeu A. I., Huzayeuski Yu. N., Salmin R. M.   +3 more
doaj   +1 more source

A rectal cancer organoid platform to study individual responses to chemoradiation

, 2019
Rectal cancer (RC) is a challenging disease to treat that requires chemotherapy, radiation and surgery to optimize outcomes for individual patients. No accurate model of RC exists to answer fundamental research questions relevant to patients.
Rectal cancer organoid platform
core  

Biodegradable Acoustic Targeting for Ultrasound‐Supported Gene Therapy (BATUS) in Glioblastoma

Advanced Science, EarlyView.
ABSTRACT Glioblastoma (GBM) remains one of the most challenging brain malignancies due to the restrictive nature of the blood–brain barrier (BBB), which severely limits effective drug and gene delivery. To overcome this, we introduce Biodegradable Acoustic Targeting for Ultrasound‐Supported Gene Therapy (BATUS), a modular platform that enables safe ...
Gulsah Erel‐Akbaba, Jinyoung Park, Achal Duhoon, Cao Thuy Giang Nguyen, Nitu Bhaskar, Sumanta Kumar Karan, Hasan Akbaba, Parbeen Singh, Thi Bao Tram Tran, Yuhui Zhu, Zhiming Li, I'jaaz Muhammad, Xiaojun Zhang, Hoang Quan Truong, A. Daniel Davidar, Elizabeth Schmitzer, Vikas N. Vattipally, Angelica F. Lopez, Patrick Kramer, Victor M. Quiroz, Ben Bykov, Claire Hao, Amir Manbachi, Nicholas Theodore, Joshua C. Doloff, Thanh D. Nguyen   +25 more
wiley   +1 more source

Abdominoperineal resection does not decrease quality of life in patients with low rectal cancer

Clinics, 2011
PURPOSE: Issues related to body image and a permanent stoma after abdominoperineal resection may decrease quality of life in rectal cancer patients. However, specific problems associated with a low anastomosis may similarly affect quality of life for ...
Luiz Felipe de Campos-Lobato, Patricia Cristina Alves-Ferreira, Ian C. Lavery, Ravi P Kiran   +3 more
doaj   +1 more source

Approach of Colorectal Surgeons to Lower Rectal Adenocarcinomas: Results from the Turkish Society of Colon and Rectal Surgery Database [PDF]

Aim: This study aimed to analyze surgical preferences and outcomes among patients with lower rectal tumors in Türkiye using data from the national Colorectal Cancer Database of the Turkish Society of Colon and Rectal Surgery (TSCRS).
Mehmet Ali Koç, Kaan Sünter, Turkish Colorectal Cancer Database Study Group, Erman Aytaç   +3 more
core   +1 more source