The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez +4 more
wiley +1 more source
Electrified thermochemical reaction engineering with metamaterial reactors. [PDF]
Höfelmann AB +9 more
europepmc +1 more source
Cell surface CD11c as a neutrophil aging marker molecule
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki +5 more
wiley +1 more source
Impact of Regulation of Wax-Based and Bio-Oil-Based Warm-Mix Additives on the Phase Behavior and Rheological Properties of Rubber-Modified Asphalt. [PDF]
Wang W +5 more
europepmc +1 more source
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen +8 more
wiley +1 more source
Preparation and Rheological Behavior of Temperature-Resistant Hydroxypropyl Guar Gum Supramolecular Hydrogels Based on Dynamic Borate Ester Bonds. [PDF]
Xing Y +8 more
europepmc +1 more source
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata +3 more
wiley +1 more source
Mechanism-to-Deployment Engineering of NO<sub>2</sub> Gas Sensors: Materials, Interfaces, Transducers, and Environmental Validation. [PDF]
Jung D.
europepmc +1 more source
MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima +8 more
wiley +1 more source
Ti doping-induced strain engineering boosts low-temperature NH<sub>3</sub>-SCR deNO<sub>x</sub> performance and H<sub>2</sub>O/SO<sub>2</sub> resistance of Ce<sub>8</sub>MnO<sub>x</sub>. [PDF]
Guo X, Hu Y, Wu X, Shen Y.
europepmc +1 more source

