Results 241 to 250 of about 557,651 (315)

The Early Upper Palaeolithic in British caves: problems and potential Le Paléolithique supérieur ancien dans les grottes de Grande‐Bretagne : problèmes et potentiels

open access: yesJournal of the Royal Anthropological Institute, EarlyView.
Recent years have seen landmark progress in our understanding of early Homo sapiens occupation of Europe, owing to new excavations and the application of new analytical methods. Research on British sites, however, continues to lag. This is because of limitations inherent in existing cave collections, and limited options for new fieldwork at known sites.
Robert Dinnis
wiley   +1 more source

Rural Health at a Crossroads: How Policymakers Have Failed Rural America and What Can Be Done for a Healthier Tomorrow

open access: yesThe Milbank Quarterly, EarlyView.
Policy Points Rural communities have more limited access to medical care and worse health outcomes. Existing federal and state policies largely fall short in addressing rural access disparities. Rural health woes require increased government funding for providers and the embrace of alternative health delivery mechanisms, as well as expanded public ...
MICHAEL E. SHEPHERD
wiley   +1 more source

Cardiovascular Plasticity and Adaptation of High‐Altitude Birds and Mammals

open access: yesIntegrative Zoology, EarlyView.
This schematic depicts the cardiovascular adaptations of mammals and birds to high‐altitude hypoxia. It highlights key phenotypic changes in oxygen transport and cardiac responses, driven by molecular mechanisms including transcriptional regulation and genetic modifications.
Huishang She, Yanhua Qu
wiley   +1 more source

Hox Gene Variation Drives Morphological Specialization of Humpback Grouper Cromileptes altivelis

open access: yesIntegrative Zoology, EarlyView.
Cromileptes altivelis exhibits a distinctive “sunken head and humpback” morphology, formed through cranial remodeling. Genetic analyses identified unique amino acid variants in Hoxa7a and Hoxa10b, with functional tests confirming their role in enhancing osteoblast activity and driving cranial remodeling.
Xiaoying Cao   +4 more
wiley   +1 more source

Metabolome Diversity Enhances Resistance of Intertidal Clams to Thermal Stress

open access: yesIntegrative Zoology, EarlyView.
Meretrix species are widely distributed intertidal bivalves in China with significant ecological and economic importance, which are sensitive to thermal stress. Our results showed that thermal environments of clam habitats shaped metabolome diversity, which can enhance the resistance of intertidal clams to thermal stress.
Zhi Hu   +5 more
wiley   +1 more source

Analysis of the nursing diagnosis of [ineffective breathing pattern (00032)] in patients hospitalized with COVID‐19: A cross‐sectional study

open access: yesInternational Journal of Nursing Knowledge, EarlyView.
Abstract Purpose To analyze the prevalence, accuracy of clinical indicators and related factors of the nursing diagnosis of ineffective breathing pattern (00032) in patients hospitalized due to COVID‐19. Methods This is a cross‐sectional study conducted in a public hospital, involving 250 adult hospitalizations between 2020 and 2021.
Caio Rodrigo Menezes dos Santos   +3 more
wiley   +1 more source

Exhaled Volatile Organic Compounds Identify Allergic Patients Among Individuals With Chronic Rhinitis

open access: yesAllergy, EarlyView.
Exhaled decane and nonadecane discriminate allergic (AR + LAR) from non‐allergic (NAR + HC) subjects among individuals with chronic rhinitis. LAR patients display higher levels of exhaled nonadecane than NAR individuals at baseline. Subjects with FeNO≥ 25 ppb have higher levels of exhaled decane, nonanal, and styrene than individuals with FeNO < 25 ppb
Rosa Alba Sola‐Martinez   +9 more
wiley   +1 more source

Resolving Endoplasmic Reticulum‐Protein Misfolding Restores Corticosteroid Sensitivity in Experimental Models of Severe Asthma

open access: yesAllergy, EarlyView.
This study investigates the role of ER stress in steroid resistance in severe asthma. Results from advanced 3D models of human bronchial epithelial cells, steroid‐resistant severe asthma mouse models, and human severe asthma sputum samples show that treatment with ICS in combination with the ER stress inhibitor 4‐PBA significantly enhances steroid ...
Prabuddha S. Pathinayake   +8 more
wiley   +1 more source

Safer prehospital anaesthesia: updated guidelines from the Association of Anaesthetists

open access: yesAnaesthesia, EarlyView.
Summary Introduction Prehospital emergency anaesthesia is recognised as a high‐risk clinical intervention. These updated guidelines consider changes in prehospital practice and parallel changes in the practice of in‐hospital emergency anaesthesia, with the aim of encouraging standardised safe anaesthetic practice in a challenging clinical area.
David Lockey   +9 more
wiley   +1 more source

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