Results 31 to 40 of about 585,310 (230)
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung+6 more
wiley +1 more source
Immunoregulatory mechanisms of the arachidonic acid pathway in cancer
The central role of the arachidonic acid (AA) pathway in anticancer immunity. Enzymes and metabolites of the AA pathway can play both immunosuppressive and immunostimulatory roles in the tumor microenvironment. Therefore, their tailored targeting could be beneficial as a standalone therapy or in combination with current cancer immunotherapy.
Maria Tredicine+3 more
wiley +1 more source
Unsupervised HDR Image and Video Tone Mapping via Contrastive Learning [PDF]
Capturing high dynamic range (HDR) images (videos) is attractive because it can reveal the details in both dark and bright regions. Since the mainstream screens only support low dynamic range (LDR) content, tone mapping algorithm is required to compress the dynamic range of HDR images (videos).
arxiv
Governance factors affecting internal auditors' ethical decision making: an exploratory study [PDF]
Purpose This paper explores the ethical decision making of internal auditors and the impact of corporate governance mechanisms thereon. It also explores whether ethical decision making is influenced by years of experience in internal auditing.
O'Leary, Conor, Stewart, Jenny
core +2 more sources
Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga+6 more
wiley +1 more source
High tone lowering and raising in Tsua [PDF]
The Tsua language is an Eastern Kalahari Khoe language of Botswana (Chebanne 2014). Tsua tone production displays complex Fundamental Frequency (F0) trajectories. Lexical data show that this language has three tone levels: High (H), Mid (M), and Low (L),
Chebanne, Andy Monthusi+1 more
core +1 more source
The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva+1 more
wiley +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Abstract Purpose To assess whether the joint application of hybrid iterative reconstruction (HIR) and an adaptive filter (AF) could reduce streak artifacts and improve image quality of neck‐and‐shoulder computed tomography (CT). Methods This study included 96 patients with suspicious neck lesions who underwent a routine nonenhanced scan on a 64‐slice ...
Wenfeng Jin+6 more
wiley +1 more source
Perceptual Experience Analysis for Tone-mapped HDR Videos based on EEG and Peripheral Physiological Signals [PDF]
High dynamic range (HDR) imaging has been attracting much attention as a technology that can provide immersive experience. Its ultimate goal is to provide better quality of experience (QoE) via enhanced contrast. In this paper, we analyze perceptual experience of tone-mapped HDR videos both explicitly by conducting a subjective questionnaire assessment
arxiv +1 more source