Results 121 to 130 of about 15,212,236 (344)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Nos conditions d’existence

open access: yesItinéraires
The Manifesto of low voltage stands as a collaborative text, penned by multiple authors. Born out of experiences in the art sphere, its schools, its arenas of reflection or struggle, this Manifesto reflects the contradictions inherent in artists' lives ...
Le Cabaret Courant Faible
doaj   +1 more source

Pseudo-gradient Based Local Voltage Control in Distribution Networks

open access: yes, 2015
Voltage regulation is critical for power grids. However, it has become a much more challenging problem as distributed energy resources (DERs) such as photovoltaic and wind generators are increasingly deployed, causing rapid voltage fluctuations beyond ...
Chen, Lijun   +2 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Impact of distributed generation and energy storage systems on electrical power distribution systems

open access: yesMaskana, 2017
Worldwide is the concern about climate change and the impact on our planet indisputable. One of the aspects that enhances environmental problems is the generation of energy through conventional methods.
Paúl Aucapiña   +4 more
doaj  

Accelerating Mini-Grid Development: An Automated Workflow for Design, Optimization, and Techno-Economic Assessment of Low-Voltage Distribution Networks

open access: yesEnergies
Reliable and efficient low-voltage distribution networks are critical for scaling mini-grid deployment and advancing universal electricity access, yet prevailing design practices remain manual, heuristic, and difficult to scale.
Ombuki Mogaka   +6 more
doaj   +1 more source

A Low-Voltage Electronically Tunable MOSFET-C Voltage-Mode First-Order All-Pass Filter Design [PDF]

open access: yes, 2013
This paper presents a simple electronically tunable voltage-mode first-order all-pass filter realization with MOSFET-C technique. In comparison to the classical MOSFET-C filter circuits that employ active elements including large number of transistors ...
Cicekoglu, O., Herencsar, N., Metin, B.
core   +1 more source

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