Results 61 to 70 of about 928,972 (342)

Strength through diversity: how cancers thrive when clones cooperate

open access: yesMolecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken   +3 more
wiley   +1 more source

Effect of the standard levels of forest road segments on soil loss

open access: yesJournal of Forest Science, 2021
Roads with the low standard level are often more susceptible to soil loss and production of sediment during rainfall events. The main aims of this research were to investigate the relationships between the standard level of the road and soil loss and ...
Ghaffar Yolmeh   +3 more
doaj   +1 more source

Cities, traffic, and CO2: A multidecadal assessment of trends, drivers, and scaling relationships [PDF]

open access: yes, 2015
Emissions of CO2 from road vehicles were 1.57 billion metric tons in 2012, accounting for 28% of US fossil fuel CO2 emissions, but the spatial distributions of these emissions are highly uncertain.
Gately, Conor K.   +2 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

2 + 1 Highways: Overview and Future Directions [PDF]

open access: yes, 2018
Most of the rural transportation system is composed of two-lane highways, and many of them serve as the primary means for rural access to urban areas and freeways.
Martin Gasulla, Marilo   +2 more
core   +3 more sources

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

open access: yesFEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito   +3 more
wiley   +1 more source

The toll of the automobile [PDF]

open access: yes, 2003
Animal-vehicle collisions are a common phenomenon worldwide, causing injury or death to millions of animals and hundreds of human passengers each year. Collision numbers can be significant to species conservation, wildlife management, traffic safety, as ...
Seiler, Andreas
core  

The usage of cement for soil stabilisation in construction of low volume roads in Malaysia

open access: yesIOP Conference Series: Materials Science and Engineering, 2019
There are about 25% of the total road networks in Malaysia is an unpaved road which is contained gravel or earth road [1]. These are commonly referred to as the low volume roads or unpaved rural road or agriculture roads which required a very minimum ...
R. Razali, Mohamad Shukor Che Malek
semanticscholar   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

Efecto del contenido de solventes en la respuesta mecánica y la compactabilidad de mezclas asfálticas elaboradas con crudo pesado de pavimentación de Castilla

open access: yesIngeniería y Ciencia, 2020
Los crudos pesados de pavimentación (CPPs) son asfaltos líquidos naturales compuestos por un alto contenido de cemento asfáltico y una porción de solventes.
Allex E Alvarez-Lugo   +2 more
doaj   +1 more source

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