Results 91 to 100 of about 3,038,209 (307)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Comprehensive versus Selective Schooling in England in Wales: What Do We Know? [PDF]

British secondary schools moved from a system of extensive and early selection and tracking in secondary schools to one with comprehensive schools during the 1960s and 70s.
Alan Manning, Jörn-Steffen Pischke
core  

Secondary school pupils' preferences for different types of structured grouping practices [PDF]

, 2006
The aim of this paper is to explore pupils’ preferences for particular types of grouping practices an area neglected in earlier research focusing on the personal and social outcomes of ability grouping. The sample comprised over 5,000 year 9 pupils (aged
Ball S. J., Barker Lunn J. C., Boaler J., Chaplain R., Department of Education and Science, Eilam B., Essen J., Findlay W., Fogelman K., Gamoran A., Hallam S., Hallam S., Hallinan M., Harlen W., Hughes M., Ireson J., Jackson B., Judith Ireson, Kulik C.‐L. C., Lacey C., Marsh H. W., McIntyre H., Neave G., Newbold D., Oakes J., Oakes J., Oakes J., Reid M. E., Rosenbaum J. E., Rosenberg M., Slavin R. E., Sukhnandan L., Susan Hallam, Taylor N., Waxman H. C.   +34 more
core   +3 more sources

School Violence Prevention Education for Lower Secondary School Students

East African Scholars Journal of Education, Humanities and Literature
School violence has become an alarming social issue, directly affecting the mental and physical health as well as the overall development of students, especially those at the lower secondary level—a stage marked by significant psychological and behavioral changes.
openaire   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

The Formation of School Peer Groups: Pupils’ Transition from Primary to Secondary School in England [PDF]

This paper examines the transitions from primary to secondary school for a contemporary cohort of children moving between state schools in England. It uses data on over 12,000 primary schools, over 2000 secondary schools and around 400,000 pupils.
Carol Propper, Deboarh Wilson, Ron Johnston, Simon Burgess, Tomas Key   +4 more
core  

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

LGBT Issues in Norwegian Textbooks

Nordic Journal of Comparative and International Education, 2018
In Norway, a model for schools’ teaching about LGBT issues is chosen where the responsibility is divided between different school subjects: social science, natural science, RLE2 (religion, philosophies of life and ethics), Norwegian and English.
Bjørn Smestad
doaj   +1 more source

Relational and interactional dynamic network data from Czech lower-secondary school students. [PDF]

Data Brief, 2023
Lintner T, Šeďová K, Sedláček M, Šalamounová Z, Švaříček R, Malíková K, Rozmahel I, Vlček J, Nekardová B.   +8 more
europepmc   +1 more source