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The lower esophageal sphincter
Neurogastroenterology & Motility, 2011AbstractThe lower esophageal sphincters (LES) together with the crural diaphragm are the major antireflux barriers protecting the esophagus from reflux of gastric content. However, reflux of gastric contents into the esophagus is a normal phenomenon in healthy individuals occurring primarily during episodes of transient lower esophageal sphincter ...
Ronnie Fass +2 more
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Lower Esophageal Sphincter Pressure as an Index of Lower Esophageal Sphincter Strength
Gastroenterology, 1970The ability of pressures measured in the lower esophageal sphincter to assess accurately the strength of the sphincter cannot be evaluated without a suitable objective measurement of sphincter strength. This study describes a measurement of strength and compares it with sphincter pressure.
Lauran D. Harris +3 more
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Disorders of the Lower Esophageal Sphincter
Annual Review of Medicine, 1975The junction of the esophagus and stomach in man is marked by a zone of elevated pressure which has been called the lower esophageal sphincter (LES) (1, 2). The purpose of this sphincter mechanism is to prevent regurgitation of gastric contents from a positive pressure cavity into the esophagus which maintains a pressure negative to the atmosphere (3 ...
R S Fisher, S Cohen
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Lower Esophageal Sphincter in Reflux Esophagitis
Scandinavian Journal of Gastroenterology, 1976Lower esophageal sphincter pressure (LESP) was studied by intraluminal perfusion-manometry in the resting state and after graded intravenous doses of pentagastrin in 12 healthy subjects and 27 patients with reflux esophagitis. These patients were classified as having ulcerative (11) or non-ulcerative esophagitis (16) by histological examination and ...
U Scheurer, F Halter
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The hypertensive lower esophageal sphincter
The American Journal of Surgery, 1996This study defines the entity of the hypertensive lower esophageal sphincter (HLES) and its treatment, including surgical implications.Esophageal manometry was performed on 1,300 patients. Of these, 53 (4%) had HLES with resting pressure > 26.5 mm Hg, defined as the upper limit of normal resting LES pressure.
Paul R. Hinder +6 more
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Transient lower esophageal sphincter relaxation
Gastroenterology, 1995RAVINDER K. MITTAL,* RICHARD H. HOLLOWAY,* ROBERTO PENAGINI, § L. ASHLEY BLACKSHAW, t and JOHN DENT* *Department of Internal Medicine, University of Virginia, Charlottesville, Virginia; *Gastrointestinal Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia; and §Cattedra di Gastroenterologia, Istituto di Scienze Mediche, University ...
R. K. Mittal +4 more
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Lower esophageal sphincter pressure in histologic esophagitis
Digestive Diseases and Sciences, 1980The fasting lower esophageal sphincter pressure of 18 normal volunteers was compared to 22 patients with symptoms and objective evidence of gastroesophageal reflux. Lower esophageal sphincter pressure was measured by rapid pull-through using an 8-lumen radially perfused catheter that sampled pressure every45 degrees around the circumference of the ...
Richard W. Welch +5 more
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Lower Esophageal Sphincter Dysfunction in Achalasia
Gastroenterology, 1971In patients with achalasia, lower esophageal sphincter (LES) dysfunction plays an important role in the impairment of esophageal emptying. To evaluate this dysfunction, the manometric characteristics of the LES were recorded for 20 normals and for 16 patients with achalasia, both before and after pneumatic dilation.
Sidney Cohen, William Lipshutz
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