Results 121 to 130 of about 11,531 (143)

The lower esophageal sphincter in health and disease

The American Journal of Surgery, 1988
The ability of the lower esophageal sphincter to protect the esophageal mucosa from exposure to gastric juice depends on its resting pressure, length exposed to abdominal pressure, and overall length. Mechanical incompetency of the sphincter can occur when one or more of these components fail. The purpose of this study was to measure manometrically the
Kari Erik Johansson, Tom R. DeMeester, Giovanni Zaninotto, Shih Chuan Cheng, Werner Schwizer   +4 more
openaire   +3 more sources

The Lower Esophageal Sphincter

2014
The lower esophageal sphincter (LES) is a complex area of circular muscle on the distal esophagus and proximal stomach several centimeters in length. Together with the diaphragmatic crura and the structure of the angle of His, the LES makes up the backbone of the gastroesophageal reflux barrier.
Steven R. DeMeester, Christina L. Greene
openaire   +2 more sources

Correlation of lower esophageal mucosal ring and lower esophageal sphincter pressure [PDF]

Digestive Diseases and Sciences, 1994
We assessed the relationship of lower esophageal sphincter pressure (LESP) to presence and absence of lower esophageal mucosal ring (LEMR) in 66 patients to determine if the LEMR was more likely related to prolonged sphincter hypotension. This potential relationship is of interest because LEMR may be due to reflux esophagitis.
David W. Gelfand, Donna Donati, Wallace C. Wu, David J. Ott, Michael Y. M. Chen   +4 more
openaire   +2 more sources

Transient Lower Esophageal Sphincter Relaxations and Mechanical Incompetence of the Lower Esophageal Sphincter – Is There a Relationship?

Journal of Surgery and Research, 2020
Introduction: The detailed process of a gastroesophageal reflux event is still under controversial discussion. Gastroenterologists have developed and favor the concept of Transient Lower esophageal Sphincter Relaxations (TLESR`s) as the major cause of gastroesophageal reflux episodes. TLESR`s are related with reflux episodes both in healthy individuals
Stephan M. Freys, Karl-Hermann Fuchs, Tom R. DeMeester   +2 more
openaire   +2 more sources

Physiology and Pathophysiology of the Lower Esophageal Sphincter

Annals of Otology, Rhinology & Laryngology, 1975
The physiologic factors controlling lower esophageal sphincter (LES) function are interrelated in a complex fashion and include the autonomic nerve supply, gastrointestinal hormones, and specific characteristics of the circular smooth muscle at the esophagogastric junction.
openaire   +3 more sources

Pathogenesis of Lower-Esophageal-Sphincter Incompetence

New England Journal of Medicine, 1973
Abstract Since patients with symptomatic gastroesophageal reflux have diminished lower-esophagealsphincter pressure, we studied the pathogenesis of this diminished sphincteric pressure. In 23 patients with symptomatic reflux as compared to 20 controls, the lower-esophageal-sphincter response to direct muscle stimulation by a parasympathomimetic drug ...
R. D. Gaskins, J. Sode, W. M. Lukash, W. H. Lipshutz   +3 more
openaire   +3 more sources

Resting pressures in the lower esophageal sphincter

The American Journal of Digestive Diseases, 1974
Interdeglutive pressures of the lower esophageal sphincter (LES) were studied by nonpullthrough techniques in 36 volunteers. Resting pressures did not remain at the high levels observed when the LES was entered. In 30 studies a gradual protracted decay ranging from 5 to 18 mm Hg was observed. These studies suggest that the LES may not pose a continuous
Alan Bloom, Simeon Carvajal, Rungruang Varadee, Murray Davidson, Marta Stekelman   +4 more
openaire   +3 more sources

Gastrin and Lower Esophageal Sphincter Tone

Archives of Internal Medicine, 1978
The gastrointestinal polypeptide gastrin, found in great abundance in the gastric antrium, was shown in 1970 to have a very dramatic effect in stimulating the smooth muscle segment of the lower esophageal sphincter (LES), and in causing marked increases in pressure in this region.
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Hypertensive Lower Esophageal Sphincter: A Reappraisal

Southern Medical Journal, 1978
The hypertensive lower esophageal sphincter (LES) is defined as one with normal relaxation and an average LES-intragastric pressure gradient greater than or equal to 40 mm Hg. Case histories of two patients with hypertensive LES and normal peristalsis in the body of the esophagus are contrasted to that of a patient with a hypertensive LES and diffuse ...
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Lower esophageal sphincter function in cirrhosis

The American Journal of Digestive Diseases, 1977
Lower esophageal sphincter (LES) function in cirrhosis was evaluated using an infused manometric system. LES pressure (LESP) in 10 subjects with cirrhosis (22 +/- 1 mm Hg) (mean +/- SE) was not significantly (P greater than 0.05) different from that of 10 control subjects (21 +/- 1 mm Hg) but was significantly (P less than 0.01) greater than the LESP ...
openaire   +3 more sources