Results 41 to 50 of about 381,363 (294)

Phylogenetic analysis of microbial communities in different regions of the gastrointestinal tract in Panaque nigrolineatus, a wood-eating fish

, 2012
The Neotropical detritivorous catfish Panaque nigrolineatus imbibes large quantities of wood as part of its diet. Due to the interest in cellulose, hemi-cellulose and lignin degradation pathways, this organism provides an interesting model system for the
McDonald, R., Watts, Joy, Joy E. M. Watts (124946), Schreier, H., Ryan McDonald, Joy E M Watts, Ryan McDonald (74014), Harold J. Schreier (124940), Harold J Schreier   +8 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Over-the-scope clips in the treatment of gastrointestinal tract iatrogenic perforation: a multicenter retrospective study and a classification of gastrointestinal tract perforations [PDF]

, 2016
AIM: To determine the outcome of the management of iatrogenic gastrointestinal tract perforations treated by over-the-scope clip (OTSC) placement. METHODS: We retrospectively enrolled 20 patients (13 female and 7 male; mean age: 70.6 ± 9.8 years) in ...
Carmelo Luigiano, Enrico Antonucci, Rita Conigliaro, Alberto Arezzo, Massimiliano Mutignani, Angelo Caruso, Giuseppe Galloro, Raffaele Manta, Filippo Mocciaro, Arezzo, Alberto, Roberto Di Mitri, Benedetto Mangiavillano, Nico Pagano, Enzo Masci   +13 more
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Comparison of risk scores for predicting adverse outcomes in acute lower gastrointestinal bleeding

Heliyon
Objective: Acute lower gastrointestinal bleeding is a common emergency in gastroenterology. Currently, there is insufficient information to predict adverse outcomes in patients with acute lower gastrointestinal bleeding.
Chenyang Li, Ningning Zhang, Yuying Zhang, Nan Guo, Xiaomeng Sun, Shuling Li, Yan Xu, Tao Wang, Chao Chen   +8 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Potential impact of Helicobacter pylori-related metabolic syndrome on upper and lower gastrointestinal tract oncogenesis.

, 2018
Both Helicobacter pylori infection and metabolic syndrome present significant global public health burdens. Metabolic syndrome is closely related to insulin resistance, the major underlying mechanism responsible for metabolic abnormalities, and ...
Giartza-Taxidou, Evaggelia, Vardaka, Elizabeth, Polyzos, Stergios A, Doulberis, Michael, Mantzoros, Christos S, Vlachaki, Efthymia, Zeglinas, Christos, Deretzi, Georgia, Kountouras, Jannis, Kazakos, Evangelos, Katsinelos, Panagiotis, Artemaki, Fotini, Tzivras, Dimitri   +12 more
core   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

GASTROINTESTINAL PROBLEMS ASSOCIATED WITH THE EXTENSIVE USE OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS IN CHILDREN

Вопросы современной педиатрии, 2014
The article discusses the mechanisms of action, different effects of non-steroidal anti-inflammatory drugs, an agreed view on the risks of damages to the upper and lower gastrointestinal tract induced by these drugs, as well as ways to eliminate them ...
N. I. Ursova
doaj   +1 more source

Advances in Oral Drug Delivery for Regional Targeting in the Gastrointestinal Tract - Influence of Physiological, Pathophysiological and Pharmaceutical Factors

Frontiers in Pharmacology, 2020
The oral route is by far the most common route of drug administration in the gastrointestinal tract and can be used for both systemic drug delivery and for treating local gastrointestinal diseases.
Susan Hua, Susan Hua
doaj   +1 more source