Results 111 to 120 of about 259,922 (311)

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Kartagener’s Syndrome

Gomal Journal of Medical Sciences, 2004
Lower respiratory tract infections are a common problem in our society. In recurrent lower respiratory tract infections the cause may be either general impairment of immune mechanism, abnormalities of mucus or abnormalities of cilia.
Ihsan-ullah Mahsud, Shahab ud Din
doaj  

Leucine‐Dependent SLC7A5–PGAM5 Interaction Promotes Advanced Atherosclerosis Through Hindering Mitochondrial Function of Macrophages

Advanced Science, EarlyView.
Higher plasma leucine is associated with increased risk of new‐onset myocardial infarction. Leucine deprivation alleviates advanced atherosclerosis in mice. Tumor‐induced leucine deprivation reprograms macrophage metabolism and increases CD5Lhi macrophages in mouse plaques. Mechanistically, leucine deficiency reduced SLC7A5‐PGAM5 binding in macrophages,
Shan Zhong, Xueyu Wang, Qingsong Li, Siqi Wang, Bin Sun, Wenjun Ni, Gengyu Zhou, Fan Wang, Xianwei Xie, Cheng Jin, Gang Xu, Peng Zhao, Xiang Peng, Feiyuan Han, Xiangwen Xi, Yidan Wang, Juan Xu, Yue Wang, Xia Gu, Shuo Li, Jian Zhang, Shuijie Li, Jinwei Tian   +22 more
wiley   +1 more source

Effectiveness of Pre‐Transplant Dual GLP‐1 Receptor Agonist and SGLT2 Inhibitor Therapy on All‐Cause Mortality in Organ Transplantation Candidates with Obesity and Type 2 Diabetes: a Target‐Trial Emulation

Advanced Science, EarlyView.
This target trial emulation in solid organ transplant candidates with obesity and type 2 diabetes evaluates whether pre‐transplant dual therapy with GLP‐1 receptor agonists plus SGLT2 inhibitors is associated with post‐transplant mortality and kidney graft outcomes compared with monotherapy or usual care, using multinational electronic health records ...
Yu‐Nan Huang, Min‐Yu Tsou, Pin‐Hung Li, Jo‐Ching Chen, Yen‐Liang Liu, Gideon Meyerowitz‐Katz, Tsung‐Hsun Tsai, Pen‐Hua Su   +7 more
wiley   +1 more source

Efficacy and safety of inhaled ambroxol solution in improving sputum of lower respiratory tract infection in children: a multicenter, randomized, double-blind, placebo-controlled trial

BMC Pulmonary Medicine
Objective To evaluate the efficacy and safety of inhaled ambroxol solution in improving sputum of lower respiratory tract infections (LRTIs) in children.
Baoping Xu, Peng Han, Yunxiao Shang, Huanji Cheng, Zhiying Han, Lin Zhao, Shaoru He, Min Lu, Enmei Liu, Kunling Shen   +9 more
doaj   +1 more source

Bedside clinical assessment predicts recurrence after hospitalization due to viral lower respiratory tract infection in young children

, 2019
Maria Arroyo, K. Salka, Geovanny F. Pérez, Carlos E. Rodríguez‐Martínez, José A. Castro‐Rodríguez, Gustavo Niño   +5 more
openalex   +2 more sources

Human Respiratory Syncytial Virus and Hospitalization of Young Children with Lower Respiratory Tract Infection in Marrakech, Morocco [PDF]

, 2020
N. Daoudi, Hajar Saffour, Ghizlane Draïss, Nourreddine Rada, Mohammed Bouskraoui, Youssef Mouaffak, Saïd Younous, Fatiha Bennaoui, Nadia El idrissi Sliline, Fadl Mrabih Rabou Maouainine, Nabila Soraa   +10 more
openalex   +1 more source

The Role of the Respiratory Microbiome and Viral Presence in Lower Respiratory Tract Infection Severity in the First Five Years of Life [PDF]

, 2021
Ivo Hoefnagels, Josephine van de Maat, Jeroen J. A. van Kampen, Annemarie M. C. van Rossum, Charlie C. Obihara, Gerdien A. Tramper‐Stranders, Astrid P. Heikema, Willem de Koning, Anne-Marie van Wermerskerken, Deborah Horst-Kreft, Gertjan J. Driessen, Janine Punt, Frank J. Smit, Andrew Stubbs, Jeroen G. Noordzij, John P. Hays, Rianne Oostenbrink   +16 more
openalex   +1 more source

Nanozymes Integrated Biochips Toward Smart Detection System

Advanced Science, EarlyView.
This review systematically outlines the integration of nanozymes, biochips, and artificial intelligence (AI) for intelligent biosensing. It details how their convergence enhances signal amplification, enables portable detection, and improves data interpretation.
Dongyu Chen, Wang Zheng, Zhihui Zhang, Shenping Yu, Xinxin Hang, Han Wu, Xiao‐Wei Xiang, Wei Mu, Yanli Jiao, Zaizai Dong, Lingqian Chang   +10 more
wiley   +1 more source

Lower respiratory tract infection [PDF]

Clinical Microbiology and Infection, 1999
openaire   +1 more source